[HTML][HTML] Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2

I Tamai, R Ohashi, J Nezu, H Yabuuchi, A Oku… - Journal of Biological …, 1998 - ASBMB
Primary carnitine deficiency, because of a defect of the tissue plasma membrane carnitine
transporters, causes critical symptoms. However, the transporter has not been molecularly …

Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family

I Tamai, J Nezu, H Uchino, Y Sai, A Oku… - Biochemical and …, 2000 - Elsevier
We identified three novel transporters structurally belonging to the organic anion transporting
polypeptide (OATP) family in humans. Since previously known rat oatp1 to 3 do not …

SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria

…, J Yamaguchi, T Nakanishi, I Tamai - … & drug disposition, 2014 - Wiley Online Library
Sodium glucose cotransporter 2 (SGLT2) inhibitors have been reported to lower the serum
uric acid (SUA) level. To elucidate the mechanism responsible for this reduction, SUA and the …

Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter

J Nezu, I Tamai, A Oku, R Ohashi, H Yabuuchi… - Nature …, 1999 - nature.com
Primary systemic carnitine deficiency (SCD; OMIM 212140) is an autosomal recessive disorder
characterized by progressive cardiomyopathy, skeletal myopathy, hypoglycaemia and …

Cloning and characterization of a novel human pH‐dependent organic cation transporter, OCTN1

I Tamai, H Yabuuchi, J Nezu, Y Sai, A Oku… - FEBS …, 1997 - Wiley Online Library
cDNA for a novel proton/organic cation transporter, OCTN1, was cloned from human fetal liver
and its transport activity was investigated. OCTN1 encodes a 551‐amino acid protein with …

Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane

…, T Nozawa, K Imai, J Nezu, A Tsuji, I Tamai - Journal of pharmacology …, 2003 - ASPET
Some organic anions are absorbed from the gastrointestinal tract through carrier-mediated
transport mechanism(s), which may include proton-coupled transport, anion exchange …

Transporter-mediated permeation of drugs across the blood–brain barrier

I Tamai, A Tsuji - Journal of pharmaceutical sciences, 2000 - Elsevier
Drug distribution into the brain is strictly regulated by the presence of the blood–brain barrier
(BBB) that is formed by brain capillary endothelial cells. Since the endothelial cells are …

Carrier-mediated intestinal transport of drugs

A Tsuji, I Tamai - Pharmaceutical research, 1996 - Springer
Recent advances in the field of carrier-mediated intestinal absorption of of amino acids,
oligopeptides, monosaccharides, monocarboxylic acids, phosphate, bile acids and several water…

Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human

T Nozawa, K Imai, JI Nezu, A Tsuji, I Tamai - Journal of Pharmacology and …, 2004 - ASPET
The pH-sensitive activity of human organic anion transporting polypeptide OATP-B, which is
expressed at the apical membrane of human small intestinal epithelial cells, was …

Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations

H Yabuuchi, I Tamai, JI Nezu, K Sakamoto, A Oku… - … of Pharmacology and …, 1999 - ASPET
In the present study, functional characteristics of organic cation transporter (OCTN)1, which
was cloned as the pH-dependent tetraethylammonium (TEA) transporter when expressed in …