[HTML][HTML] Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
I Tamai, R Ohashi, J Nezu, H Yabuuchi, A Oku… - Journal of Biological …, 1998 - ASBMB
Primary carnitine deficiency, because of a defect of the tissue plasma membrane carnitine
transporters, causes critical symptoms. However, the transporter has not been molecularly …
transporters, causes critical symptoms. However, the transporter has not been molecularly …
Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
I Tamai, J Nezu, H Uchino, Y Sai, A Oku… - Biochemical and …, 2000 - Elsevier
We identified three novel transporters structurally belonging to the organic anion transporting
polypeptide (OATP) family in humans. Since previously known rat oatp1 to 3 do not …
polypeptide (OATP) family in humans. Since previously known rat oatp1 to 3 do not …
SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria
…, J Yamaguchi, T Nakanishi, I Tamai - … & drug disposition, 2014 - Wiley Online Library
Sodium glucose cotransporter 2 (SGLT2) inhibitors have been reported to lower the serum
uric acid (SUA) level. To elucidate the mechanism responsible for this reduction, SUA and the …
uric acid (SUA) level. To elucidate the mechanism responsible for this reduction, SUA and the …
Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter
J Nezu, I Tamai, A Oku, R Ohashi, H Yabuuchi… - Nature …, 1999 - nature.com
Primary systemic carnitine deficiency (SCD; OMIM 212140) is an autosomal recessive disorder
characterized by progressive cardiomyopathy, skeletal myopathy, hypoglycaemia and …
characterized by progressive cardiomyopathy, skeletal myopathy, hypoglycaemia and …
Cloning and characterization of a novel human pH‐dependent organic cation transporter, OCTN1
I Tamai, H Yabuuchi, J Nezu, Y Sai, A Oku… - FEBS …, 1997 - Wiley Online Library
cDNA for a novel proton/organic cation transporter, OCTN1, was cloned from human fetal liver
and its transport activity was investigated. OCTN1 encodes a 551‐amino acid protein with …
and its transport activity was investigated. OCTN1 encodes a 551‐amino acid protein with …
Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane
…, T Nozawa, K Imai, J Nezu, A Tsuji, I Tamai - Journal of pharmacology …, 2003 - ASPET
Some organic anions are absorbed from the gastrointestinal tract through carrier-mediated
transport mechanism(s), which may include proton-coupled transport, anion exchange …
transport mechanism(s), which may include proton-coupled transport, anion exchange …
Transporter-mediated permeation of drugs across the blood–brain barrier
I Tamai, A Tsuji - Journal of pharmaceutical sciences, 2000 - Elsevier
Drug distribution into the brain is strictly regulated by the presence of the blood–brain barrier
(BBB) that is formed by brain capillary endothelial cells. Since the endothelial cells are …
(BBB) that is formed by brain capillary endothelial cells. Since the endothelial cells are …
Carrier-mediated intestinal transport of drugs
A Tsuji, I Tamai - Pharmaceutical research, 1996 - Springer
Recent advances in the field of carrier-mediated intestinal absorption of of amino acids,
oligopeptides, monosaccharides, monocarboxylic acids, phosphate, bile acids and several water…
oligopeptides, monosaccharides, monocarboxylic acids, phosphate, bile acids and several water…
Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human
T Nozawa, K Imai, JI Nezu, A Tsuji, I Tamai - Journal of Pharmacology and …, 2004 - ASPET
The pH-sensitive activity of human organic anion transporting polypeptide OATP-B, which is
expressed at the apical membrane of human small intestinal epithelial cells, was …
expressed at the apical membrane of human small intestinal epithelial cells, was …
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations
H Yabuuchi, I Tamai, JI Nezu, K Sakamoto, A Oku… - … of Pharmacology and …, 1999 - ASPET
In the present study, functional characteristics of organic cation transporter (OCTN)1, which
was cloned as the pH-dependent tetraethylammonium (TEA) transporter when expressed in …
was cloned as the pH-dependent tetraethylammonium (TEA) transporter when expressed in …