To evaluate whether alterations in the multidrug-resistance (MDR)-1 gene correlate with
intestinal MDR-1 expression and uptake of orally administered P-glycoprotein (PGP) substrates, …

Background P‐glycoprotein, the gene product of MDR1, confers multidrug resistance against
antineoplastic agents but also plays an important role in the bioavailability of common …

Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC)
database containing information on over 15,000 control (noncancer) subjects, the allele …

Interindividual differences of drug response are an important cause of treatment failures and
adverse drug reactions. The identification of polymorphisms explaining distinct phenotypes …

Objective The frequency of functionally important mutations and alleles of genes coding for
xenobiotic metabolizing enzymes shows a wide ethnic variation. However, little is known of …

Deposition of the β-amyloid peptide (Aβ) in the brain occurs during normal ageing and is
substantially accelerated in patients with Alzheimer's disease. Since Aβ is continuously …

Background & Aims: The human multidrug resistance 1 (MDR1) gene product P-glycoprotein
is highly expressed in intestinal epithelial cells, where it constitutes a barrier against …

Foreign compound-metabolizing enzymes may modify the risk of chemically induced cancer.
We wanted to examine enzymes with putative relevance in urinary bladder cancer using …

This study reports a C→A transversion at position 4887 in exon 7 of cytochrome P4501A1 (CYP1A1),
resulting in a threonine→asparagine exchange in codon 461. The polymorphism is …

Objective We investigated the effect of polymorphisms in the P‐glycoprotein (P‐gp) MDR1
gene on steady‐state pharmacokinetics of digoxin in Caucasians. According to earlier data, …