Free fatty acid receptors 2 and 3 (FFA2 and FFA3) are G protein-coupled receptors for short
chain free fatty acids (SCFAs). They respond to the same set of endogenous ligands but with …

The G-protein-coupled receptor free fatty acid receptor 1 (FFAR1), previously named GPR40,
is a possible novel target for the treatment of type 2 diabetes. In an attempt to identify new …

Free fatty acid receptor 2 (FFA2; GPR43) is a G protein-coupled seven-transmembrane
receptor for short-chain fatty acids (SCFAs) that is implicated in inflammatory and metabolic …

GPR40 was formerly an orphan G protein-coupled receptor whose endogenous ligands have
recently been identified as free fatty acids (FFAs). The receptor, now named FFA receptor 1…

FFA2 is a G protein-coupled receptor that responds to short chain fatty acids and has
generated interest as a therapeutic target for metabolic and inflammatory conditions. However, …

GPR40, free fatty acid receptor 1 (FFAR1), is a member of the GPCR superfamily and a
possible target for the treatment of type 2 diabetes. In this work, we conducted a bidirectional …

When it is difficult to develop selective ligands within a family of related G-protein-coupled
receptors (GPCRs), chemically engineered receptors activated solely by synthetic ligands (…

Transcription by RNA polymerase I (Pol-I) is the main driving force behind ribosome biogenesis,
a fundamental cellular process that requires the coordinated transcription of all three …

Allosteric agonists are powerful tools for exploring the pharmacology of closely related G
protein-coupled receptors that have nonselective endogenous ligands, such as the short chain …

This is an important study that contributes to our understanding of the role of beta-arrestins in
endosomal activation of the vasopressin type 2 receptors. While the use of a minigene as a …