Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) have been
recently derived and are used for basic research, cardiotoxicity assessment, and phenotypic …

Human ether-a-go-go-related gene (hERG) encodes a rapidly activating delayed rectifier
potassium channel that plays important roles in cardiac action potential repolarization. …

Lead optimization of piperidine amide HTS hits, based on an anilino-thiazole core, led to the
identification of analogs which displayed low nanomolar blocking activity at the canonical …

The purpose of this study was to test the hypothesis that differences in voltage-gated Ca 2+
channels increase with age during the development of sustained hypertension in the …

Previously we have shown that the transient receptor potential vanilloid 4 (TRPV4) channel
regulates urinary bladder function, and that TRPV4 is expressed in both smooth muscle and …

The greater efficacy of organic channel blockers in lowering peripheral resistance and
blood pressure in hypertensive subjects has been suggested to be the result of augmented …

Long and short QT syndromes associated with loss and gain of human ether-a-go-go-related
gene (hERG) channel activity, respectively, can cause life-threatening arrhythmias. As such…

The large-conductance voltage-gated and calcium-dependent K + (BK) channels are widely
distributed and play important physiological roles. Commonly used BK channel inhibitors …

Background This study was designed to test the hypothesis that differences exist in the
inactivation properties of voltage-gated Ca 2+ channels (Ca V ) in hypertensive arterial smooth …

Large conductance Ca 2+ -activated K + (BK) channels are known to be regulated by both
intracellular Ca 2+ and voltage. Although BK channel modulators have been identified, there …