Interaction between the μ opioid receptor and filamin A is involved in receptor regulation and trafficking
I Onoprishvili, ML Andria, HK Kramer… - Molecular …, 2003 - ASPET
The carboxyl tail of the human μ opioid receptor was shown to bind the carboxyl terminal
region of human filamin A, a protein known to couple membrane proteins to actin. Results from …
region of human filamin A, a protein known to couple membrane proteins to actin. Results from …
[HTML][HTML] Delta opioid activation of the mitogen-activated protein kinase cascade does not require transphosphorylation of receptor tyrosine kinases
HK Kramer, I Onoprishvili, ML Andria, K Hanna… - BMC …, 2002 - Springer
Background In this study, we investigated the mechanism(s) by which delta opioids induce
their potent activation of extracellular signal-regulated protein kinases (ERKs) in different cell …
their potent activation of extracellular signal-regulated protein kinases (ERKs) in different cell …
Filamin A mutant lacking actin-binding domain restores mu opioid receptor regulation in melanoma cells
I Onoprishvili, S Ali, ML Andria, A Shpigel… - Neurochemical …, 2008 - Springer
We have previously reported that the protein filamin A (FLA) binds to the carboxyl tail of the
mu opioid receptor (MOPr). Using human melanoma cells, which do not express filamin A, …
mu opioid receptor (MOPr). Using human melanoma cells, which do not express filamin A, …
[HTML][HTML] The bovine μ-opioid receptor: cloning of cDNA and pharmacological characterization of the receptor expressed in mammalian cells
I Onoprishvili, ML Andria, FS Vilim, JM Hiller… - Molecular brain …, 1999 - Elsevier
The cDNA coding for the bovine μ-opioid receptor has been cloned and sequenced. Conserved
sequences from murine δ-receptor cDNA were used as primers in polymerase chain …
sequences from murine δ-receptor cDNA were used as primers in polymerase chain …
Chronic morphine treatment up-regulates mu opioid receptor binding in cells lacking filamin A
I Onoprishvili, EJ Simon - Brain research, 2007 - Elsevier
We investigated the effects of morphine and other agonists on the human mu opioid receptor
(MOP) expressed in M2 melanoma cells, lacking the actin cytoskeleton protein filamin A …
(MOP) expressed in M2 melanoma cells, lacking the actin cytoskeleton protein filamin A …
The interaction between the mu opioid receptor and filamin A
EJ Simon, I Onoprishvili - Neurochemical research, 2010 - Springer
Our laboratory embarked on research to discover proteins the interaction of which with the
mu opioid receptor (MOPr) is required for its function and regulation. We performed yeast two-…
mu opioid receptor (MOPr) is required for its function and regulation. We performed yeast two-…
Inactivation of the purified bovine μ opioid receptor by sulfhydryl reagents
TL Gioannini, I Onoprishvili, JM Hiller… - Neurochemical research, 1999 - Springer
We have investigated the role of cysteine residues in a highly purified μ opioid receptor
protein (μORP) by examining the effect of -SH reagents on the binding of opioid ligands. …
protein (μORP) by examining the effect of -SH reagents on the binding of opioid ligands. …
[BOOK][B] Commentary on Georgian insurance law: Vol. I
A Borroni - 2022 - 109.205.44.60
Despite its overwhelming importance in practice, Insurance Law is regarded as a kind of an
outlier in many legal systems. Few legal curricula incorporate the subject into their lists of …
outlier in many legal systems. Few legal curricula incorporate the subject into their lists of …
Loss of Filamin A leads to heart failure in zebrafish
D Martins Bordalo - 2020 - archiv.ub.uni-heidelberg.de
Dilated Cardiomyopathy (DCM) is frequently leading to heart failure. Familial analysis revealed
30% - 60 % of cases to be of genetic cause, predominantly occurring in genes encoding …
30% - 60 % of cases to be of genetic cause, predominantly occurring in genes encoding …