[HTML][HTML] Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients
T Southworth, J Plumb, V Gupta, J Pearson, I Ramis… - Respiratory …, 2016 - Springer
Background Phosphatidylinositol 3-kinase delta (PI3Kδ) and Janus-activated kinases (JAK)
are both novel anti-inflammatory targets in asthma that affect lymphocyte activation. We have …
are both novel anti-inflammatory targets in asthma that affect lymphocyte activation. We have …
Identification of 2-imidazopyridine and 2-aminopyridone purinones as potent pan-janus kinase (JAK) inhibitors for the inhaled treatment of respiratory diseases
…, J De Alba, M Calbet, M Miralpeix, I Ramis - Journal of Medicinal …, 2019 - ACS Publications
Janus kinases (JAKs) have a key role in regulating the expression and function of relevant
inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. …
inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. …
[HTML][HTML] The pan-JAK inhibitor LAS194046 reduces neutrophil activation from severe asthma and COPD patients in vitro
J Milara, B Ballester, A de Diego, M Calbet, I Ramis… - Scientific Reports, 2022 - nature.com
Non-T2 severe asthma and chronic obstructive pulmonary disease (COPD) are airway chronic
inflammatory disorders with a poor response to corticosteroids. LAS194046, a novel pan-…
inflammatory disorders with a poor response to corticosteroids. LAS194046, a novel pan-…
Systemic prostacyclin in cirrhotic patients: relationship with portal hypertension and changes after intestinal decontamination
C Guarner, G Soriano, J Such, M Teixidó, I Ramis… - Gastroenterology, 1992 - Elsevier
The total body production of prostacyclin was shown to be increased in cirrhotic patients,
suggesting that its synthesis by blood vessels of the systemic circulation is enhanced. However, …
suggesting that its synthesis by blood vessels of the systemic circulation is enhanced. However, …
[HTML][HTML] PI3K, p38 and JAK/STAT signalling in bronchial tissue from patients with asthma following allergen challenge
T Southworth, S Mason, A Bell, I Ramis, M Calbet… - Biomarker …, 2018 - Springer
Background Inhaled allergen challenges are often used to evaluate novel asthma
treatments in early phase clinical trials. Current novel therapeutic targets in asthma include …
treatments in early phase clinical trials. Current novel therapeutic targets in asthma include …
Novel inhaled pan-JAK inhibitor, LAS194046, reduces allergen-induced airway inflammation, late asthmatic response, and pSTAT activation in brown Norway rats
M Calbet, I Ramis, E Calama, C Carreño, S Paris… - … of Pharmacology and …, 2019 - ASPET
The Janus-activated kinase (JAK) family together with signal transducer and activator of
transcription (STAT) signaling pathway has a key role in regulating the expression and function …
transcription (STAT) signaling pathway has a key role in regulating the expression and function …
A novel inhaled Syk inhibitor blocks mast cell degranulation and early asthmatic response
I Ramis, R Otal, C Carreño, A Domènech… - Pharmacological …, 2015 - Elsevier
Spleen tyrosine kinase (Syk) is essential for signal transduction of immunoreceptors. Inhibition
of Syk abrogates mast cell degranulation and B cell responses. We hypothesized that Syk …
of Syk abrogates mast cell degranulation and B cell responses. We hypothesized that Syk …
New water-soluble sulfonylphosphoramidic acid derivatives of the COX-2 selective inhibitor cimicoxib. A novel approach to sulfonamide prodrugs
…, R Ferrando, LA Gómez, I Ramis… - Journal of medicinal …, 2004 - ACS Publications
… Isabel Ramis … Isabel Ramis - Research Center, Grupo Uriach. Av. Camí Reial, 51-57, E−08184,
Palau-Solità i Plegamans, Spain …
Palau-Solità i Plegamans, Spain …
Tofacitinib ameliorates inflammation in a rat model of airway neutrophilia induced by inhaled LPS
E Calama, I Ramis, A Domènech, C Carreño… - Pulmonary …, 2017 - Elsevier
Background and purpose The Janus Kinase (JAK) family mediates the cytokine receptor-induced
signalling pathways involved in inflammatory processes. The activation of the signal …
signalling pathways involved in inflammatory processes. The activation of the signal …
The assessment of biomarkers to detect nephrotoxicity using an integrated database
…, GD Nuyts, MM Elseviers, G Hotter, I Ramis… - Environmental …, 1997 - Elsevier
Groups of industrial workers exposed to heavy metals (cadmium, mercury, and lead) or
solvents were studied together with corresponding control groups. The cohorts were collected …
solvents were studied together with corresponding control groups. The cohorts were collected …