mTORC1‐and mTORC2‐interacting proteins keep their multifunctional partners focused

I BrachoValdés, P Moreno‐Alvarez… - IUBMB …, 2011 - Wiley Online Library
The mammalian target of rapamycin, best known as mTOR, is a phylogenetically conserved
serine/threonine kinase that controls life‐defining cellular processes such as growth, …

Regulation of mTORC1 complex assembly and signaling by GRp58/ERp57

I Ramírez-Rangel, I Bracho-Valdés… - … and cellular biology, 2011 - Am Soc Microbiol
The mammalian target of rapamycin (mTOR) regulates cell growth and survival via two
different multiprotein complexes, mTORC1 and mTORC2. The assembly of these serine-…

Gβγ pathways in cell polarity and migration linked to oncogenic GPCR signaling: potential relevance in tumor microenvironment

J Vázquez-Prado, I Bracho-Valdés… - Molecular …, 2016 - ASPET
Cancer cells and stroma cells in tumors secrete chemotactic agonists that exacerbate invasive
behavior, promote tumor-induced angiogenesis, and recruit protumoral bone marrow–…

[HTML][HTML] Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch

I Bracho-Valdés, RD Cervantes-Villagrana… - International Journal of …, 2023 - mdpi.com
The serine-threonine kinase Akt plays a fundamental role in cell survival, metabolism,
proliferation, and migration. To keep these essential processes under control, Akt activity and …

[HTML][HTML] Experimental gestational diabetes mellitus induces blunted vasoconstriction and functional changes in the rat aorta

…, M Ibarra-Barajas, I Bracho-Valdés… - BioMed research …, 2014 - hindawi.com
Diabetic conditions increase vascular reactivity to angiotensin II in several studies but there
are scarce reports on cardiovascular effects of hypercaloric diet (HD) induced gestational …

Effect of pregnancy on the roles of nitric oxide and prostaglandins in 5‐hydroxytryptamine‐induced contractions in rat isolated thoracic and abdominal aorta

…, V Pérez‐Alvarez, I Bracho Valdes… - Clinical and …, 2005 - Wiley Online Library
Vascular resistance and sensitivity to circulating pressor and vasoconstrictor substances are
blunted during pregnancy. This has been attributed mainly to an increased production of …

Evidence of changes in alpha-1/AT1 receptor function generated by diet-induced obesity

…, E Querejeta, I Bracho-Valdes… - Diabetes and …, 2017 - journals.sagepub.com
To study whether hypercaloric diet–induced obesity deteriorates vascular contractility of rat
aorta through functional changes in α 1 adrenergic and/or AT1 Angiotensin II receptors. …

Increased alpha-1 adrenoceptor expression in pregnant rats with subrenal aortic coarctation

I Bracho-Valdés, D Godínez-Hernández… - Hypertension in …, 2009 - Taylor & Francis
The progression of pregnancy is associated with attenuation in vasopressor response to
adrenergic agonists. In pregnancy-induced hypertension this attenuation is reverted. It is not …

Time course of angiotensin II dependent vascular and metabolic effects of preeclampsia

P Rosas, C Tufiño, IB Valdes, RAB Lugo - Pregnancy Hypertension, 2017 - Elsevier
Pregnancy is characterized by a blunted pressor response to angiotensin II that is progressively
lost during preeclampsia complicated pregnancies. Renin angiotensin system (RAS) …

Angiotensin-II-dependent changes in alpha-1 adrenoceptor vascular expression in pregnant rats

P López-Sánchez, I Bracho Valdés… - Pharmacology, 2009 - karger.com
Vessels from pregnant animals show a blunted response to adrenergic agonists. In this work,
we explored if pregnancy reduces α 1 -adrenergic receptor (α 1 -AR)-mediated vascular …