The signaling for activation of protein tyrosine kinases (PTKs) is usually started by binding
of ligands to cell-surface receptors. However, recent evidence suggests the presence of …

Regulation of immune system is of paramount importance to prevent immune attacks against
self-components. Mice deficient in the interleukin (IL)-2/IL-15 receptor β chain, CD122, are …

We report here on a novel metallothionein-I (MT)/ret transgenic mouse line in which skin
melanosis, benign melanocytic tumor and malignant melanoma metastasizing to distant organs …

4-Hydroxynonenal (HNE), a diffusible product of lipid peroxidation, has been suggested to
be a key mediator of oxidative stress-induced cell death. In this study, we partially …

Protein tyrosine kinases (PTKs) play key roles in starting the signal transduction network for
cellular development and functions. A number of both receptor-type and non-receptor-type …

4-Hydroxynonenal (HNE), an aldehyde product of membrane lipid peroxidation, has been
suggested to mediate a number of oxidative stress-linked pathological events in humans, …

We demonstrated that products of the L-arginine-dependent pathway of human alveolar
macrophages (AM) effectively kill the Mycobacterium bovis bacillus Calmette-Guérin (BCG) in …

c-Src kinase was activated when either murine NIH3T3 fibroblast cells or immunoprecipitated
c-Src proteins were treated with nitric oxide generator, S-nitroso-N-acetyl penicillamine (…

Carbonyl compounds with diverse carbon skeletons may be differentially related to the
pathogenesis of vascular diseases. In this study, we compared intracellular signals delivered into …

The catalytic and signaling activities of RET, a receptor-type tyrosine kinase, are regulated
by the autophosphorylation of several tyrosine residues in the cytoplasmic region of RET. …