Antitumor activity, pharmacology, and toxicity of ellipticines, ellipticinium, and 9-hydroxy derivatives: preliminary clinical trials of 2-methyl-9-hydroxy ellipticinium (NSC …

C Paoletti, JB Le Pecq, N Dat-Xuong, P Juret… - Cancer Chemo-and …, 1980 - Springer
Ellipticine and some derivatives are highly cytotoxic substances which kill L1210 cells at
concentrations ranging form 10 -8 to 10 -6 M. Some compounds in this series bind with high …

Use of ethidium bromide for separation and determination of nucleic acids of various conformational forms and measurement of their associated enzymes

JB Le Pecq - Methods of biochemical analysis, 1971 - Wiley Online Library
USE OF ETHIDIUM BROMIDE FOR SEPARATION 43 dye (1, 2). On the other hand, in relation
to its ability to bind to nucleic acids, it displays several interesting biological properties, …

Dendritic cell-derived exosomes in cancer immunotherapy: exploiting nature's antigen delivery pathway

A Delcayre, H Shu, JB Le Pecq - Expert review of anticancer …, 2005 - Taylor & Francis
… Paz P, Paranjpe G, Villaflor G, Hsu DH, Le Pecq JB. A validated potency assay for dexosomes,
a novel acellular product for cancer therapy. 19th Annual Meeting International Society …

Selective loss of mitochondrial DNA after treatment of cells with ditercalinium (NSC 335153), an antitumor bis-intercalating agent

…, D Coulaud, BP Roques, JB Le Pecq - Cancer research, 1988 - AACR
… I., Porcher, G., Gosse, CH., and Le Pecq, JB DNA … Esnault, C., Roques, BP, Jacquemin-Sablon,
A., and Le Pecq, JB … Lambert, B., Roques, BP, and Le Pecq, JB Induction of an abortive …

[HTML][HTML] Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

…, C Robert, V Serra, N Valente, JB Le Pecq… - Journal of translational …, 2005 - Springer
Background DC derived-exosomes are nanomeric vesicles harboring functional MHC/peptide
complexes capable of promoting T cell immune responses and tumor rejection. Here we …

[HTML][HTML] A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

…, MA Sutton, A Delcayre, DH Hsu, JB Le Pecq… - Journal of translational …, 2005 - Springer
… , Alain Delcayre, Di-Hwei Hsu, and Jean BernardLe Pecq held stock and were employees in
Anosys, … JB L provided scientific direction regarding generation of the dexosomes, protocol …

Production and characterization of clinical grade exosomes derived from dendritic cells

…, JY Yao, S Patel, DH Hsu, C Ruegg, JB Le Pecq - Journal of …, 2002 - Elsevier
We describe methods for the production, purification, and characterization of clinical grade (cGMP)
exosomes derived from antigen presenting cells (APCs). Exosomes have been …

A new fluorometric method for RNA and DNA determination

JB Le Pecq, C Paoletti - Analytical biochemistry, 1966 - Elsevier
Previous studies have shown that a dye, ethidium bromide, markedly increases its fluorescence
when it binds to double-stranded DNA or double-stranded regions of RNA. It is shown …

Targeting Tumor Antigens to Secreted Membrane Vesicles In vivo Induces Efficient Antitumor Immune Responses

…, C Jancic, A Boissonnas, A Delcayre, JB Le Pecq… - Cancer research, 2008 - AACR
Expression of non-self antigens by tumors can induce activation of T cells in vivo, although
this activation can lead to either immunity or tolerance. CD8 + T-cell activation can be direct (if …

DNA bifunctional intercalators. 2. Fluorescence properties and DNA binding interaction of an ethidium homodimer and an acridine ethidium heterodimer. Appendix …

…, J Barbet, N Capelle, BP Roques, JB Le Pecq… - Biochemistry, 1978 - ACS Publications
… & Le Bret, 1976) and a monomeric acridine derivative (AcMo, Le Pecq et ah, 1975), were …
from competition experiment with ethidium bromide according to Le Pecq & Paoletti (1967). …