Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding
…, AS Lesage, K De Loore, JE Leysen - …, 1996 - Springer
Risperidone and its active metabolite 9-OH-risperidone were compared to reference
antipsychotic drugs (haloperidol, pipamperone, fluspirilene, clozapine, zotepine) and compounds …
antipsychotic drugs (haloperidol, pipamperone, fluspirilene, clozapine, zotepine) and compounds …
[PDF][PDF] Biochemical profile of risperidone, a new antipsychotic.
JE Leysen, W Gommeren, A Eens… - … of Pharmacology and …, 1988 - Citeseer
Materials and Methods Radioligand receptor binding and neurotransmitter uptake assays:
inhibition by drugs Female Wistar rats (150 g) or male Pirbright guinea pigs (200 g) were …
inhibition by drugs Female Wistar rats (150 g) or male Pirbright guinea pigs (200 g) were …
Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonist.
JE Leysen, W Gommeren, P Van Gompel… - Molecular …, 1985 - ASPET
In vitro and in vivo receptor-binding properties of the new serotonin antagonist, ritanserin,
are reported. In in vitro binding assays, ritanserin shows high affinity binding to serotonin-S2 …
are reported. In in vitro binding assays, ritanserin shows high affinity binding to serotonin-S2 …
Serotonergic component of neuroleptic receptors
JE Leysen, CJE Niemegeers, JP Tollenaere… - Nature, 1978 - nature.com
BINDING studies performed in vitro with 3 H-haloperidol 1–3 , 3 H-spiperone 4–5 , 3 H-dopamine
1–3,6 and 3 H-apomorphine 7,8 showed that the specific neuroleptic binding sites in …
1–3,6 and 3 H-apomorphine 7,8 showed that the specific neuroleptic binding sites in …
5-HT2 receptors
JE Leysen - Current Drug Targets-CNS & Neurological …, 2004 - ingentaconnect.com
5-HT2 receptors are G-protein coupled receptors that currently comprise threesubtypes: 5-HT2A,
5-HT2B and 5-HT2C receptors. The subtypes are related in theirmolecular structure, …
5-HT2B and 5-HT2C receptors. The subtypes are related in theirmolecular structure, …
Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity.
JE Leysen, PM Janssen, AA Megens… - The Journal of clinical …, 1994 - europepmc.org
The interaction of risperidone, 9-hydroxyrisperidone (the principal active metabolite), and
clozapine with neurotransmitter receptors was investigated in vitro using animal brain tissue …
clozapine with neurotransmitter receptors was investigated in vitro using animal brain tissue …
Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors
JE Leysen, F Awouters, L Kennis, PM Laduron… - Life sciences, 1981 - Elsevier
For a new antiserotonergic agent, R 41 468 and 13 reference compounds with alleged
antiserotonergic activity, the receptor binding profile is reported, comprising K i -values measured …
antiserotonergic activity, the receptor binding profile is reported, comprising K i -values measured …
Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: role of 5HT2 receptors
JE Leysen, PMF Janssen, A Schotte, WHML Luyten… - …, 1993 - Springer
… uptake models was measured in radioligand binding assays using tissue homogenates or
membrane preparations of cells expressing cloned receptors as described in Leysen et al. (…
membrane preparations of cells expressing cloned receptors as described in Leysen et al. (…
5-HT2A and 5-HT2C receptors and their atypical regulation properties
D Van Oekelen, WHML Luyten, JE Leysen - Life sciences, 2003 - Elsevier
The 5-HT 2A and 5-HT 2C receptors belong to the G-protein-coupled receptor (GPCR)
superfamily. GPCRs transduce extracellular signals to the interior of cells through their interaction …
superfamily. GPCRs transduce extracellular signals to the interior of cells through their interaction …
Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity
PM Laduron, JE Leysen - Biochemical pharmacology, 1979 - Elsevier
When tested in different in vitro binding assays and in dopamine-sensitive adenylate cyclase,
domperidone was found to be a very potent and specifie dopamine antagonist. Accordingly…
domperidone was found to be a very potent and specifie dopamine antagonist. Accordingly…