Materials and Methods Preparation of RNA. Human lung poly (A+) RNA was obtained as
described previously from an individual with cystic fibrosis (Gerard et al., 1990). RNA was …

In order to determine whether the morphological modifications observed in arterial media of
spontaneously hypertensive rats (SHR) could be induced by an abnormal response of the …

The purpose of this study was to explore the role of acidic amino acids in the allosteric behavior
of gallamine at the m2 receptor. This was achieved by first mutating the acidic residues …

… Different components of IPs were separated and measured as previously described (Paquet …
IC 50 , pK B and pA 2 values were calculated as previously described (Paquet et al., 1999). …

A bradykinin analogue (H-Arg-Pro-Pro-Gly-Phe-Ser-d-BT-Arg-OH, 3) in which the Pro-Phe
dipeptide was replaced by the (3S)[amino]-5-(carbonylmethyl)-2,3-dihydro-1,5-benzothiazepin…

Neutrophil recruitment to inflammatory sites is mediated by two related receptors: CXC
chemokine receptors 1 (CXCR1) and 2 (CXCR2). Both receptors share two ligands, interleukin-8 (…

We have previously shown that substitution of the d-Tic-Oic dipeptide by a (3S)-[amino]-5-(carbonylmethyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
(d-BT) moiety in the bradykinin B …

We compared the binding properties of [3 H]-desArg 10-[Leu 9]-kallidin, a radiolabelled kinin
B 1 receptor antagonist, to membranes from IMR-90 human embryonic fibroblasts and from …

We have previously synthesized a potent and selective B 1 bradykinin receptor antagonist,
JMV1645 (H-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH), containing a dipeptide mimetic ((3S)-…

We report that mutation of specific residues in the human B 2 bradykinin (BK) receptor induces
its marked constitutive activation, evaluated through inositol phosphate production in COS…