Bioactivation of halogenated hydrocarbons by cytochrome P4502E1

JL Raucy, JC Kraner, JM Lasker - Critical reviews in toxicology, 1993 - Taylor & Francis
Numerous halogenated hydrocarbons of the alkane, alkene, and alkyne classes are
metabolized by P450 enzymes to products that elicit cytotoxic and/or carcinogenic effects. Such …

Kidney dysfunction and hypertension: role for cadmium, p450 and heme oxygenases?

S Satarug, M Nishijo, JM Lasker… - The Tohoku journal of …, 2006 - jstage.jst.go.jp
1. The kidney as a critical target in non-occupationally exposed populations 183 1.1 Sources
and the half-life of Cd deposited in the human kidney 1.2 Renal Cd toxicities and adverse …

Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2

JL Raucy, JM Lasker, CS Lieber, M Black - Archives of biochemistry and …, 1989 - Elsevier
Acetaminophen (APAP), a widely used over-the-counter analgesic, is known to cause
hepatotoxicity when ingested in large quantities in both animals and man, especially when …

[HTML][HTML] Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney: role of Cyp4F2 and Cyp4A11

JM Lasker, WB Chen, I Wolf, BP Bloswick… - Journal of Biological …, 2000 - ASBMB
20-Hydroxyeicosatetraenoic acid (20-HETE), an ω-hydroxylated arachidonic acid (AA)
metabolite, elicits specific effects on kidney vascular and tubular function that, in turn, influence …

The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver

M Tsutsumi, JM Lasker, M Shimizu, AS Rosman… - Hepatology, 1989 - journals.lww.com
Perivenular hepatocytes are the first cells within the liver lobule to display signs of toxicity
following long-term alcohol use. In an attempt to explain this phenomenon, we have examined …

Metabolism of arachidonic acid to 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11

PK Powell, I Wolf, R Jin, JM Lasker - Journal of Pharmacology and …, 1998 - ASPET
20-Hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) is a principal arachidonic acid (AA)
metabolite formed viaP450-dependent oxidation in hepatic and renal microsomes. Although …

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

…, T Sullivan, S Kitareewan, JL Raucy, JM Lasker… - Biochemistry, 1994 - ACS Publications
MATERIALS AND METHODS Materials. Human liver samples were obtained from Dr. Fred
Guengerich, Vanderbilt University, Nashville, TN. Restriction endonucleases were purchased …

[PDF][PDF] Induction of cytochrome P‐4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA

T Takahashi, JM Lasker, AS Rosman, CS Lieber - Hepatology, 1993 - Wiley Online Library
The propensity of centrilobular liver damage to develop in alcohol abusers after exposure to
various hepatotoxins, including ethanol itself, has been linked to the induction by ethanol of …

[PDF][PDF] Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4.

DE Feierman, JM Lasker - Drug Metabolism and Disposition, 1996 - researchgate.net
The microsomal metabolism of fentanyl, a synthetic opioid commonly used in anesthesia,
was investigated in human liver. Incu-bation of fentanyl with human hepatic microsomes …

Digital lock-in detection for discriminating multiple modulation frequencies with high accuracy and computational efficiency

JM Masciotti, JM Lasker… - IEEE Transactions on …, 2007 - ieeexplore.ieee.org
We introduce a novel digital lock-in detection technique for simultaneously measuring the
amplitude and phase of multiple amplitude-modulated signals. Using particular modulation …