[HTML][HTML] Hypoxanthine-guanine phosophoribosyltransferase (HPRT) deficiency: Lesch-Nyhan syndrome

RJ Torres, JG Puig - Orphanet journal of rare diseases, 2007 - Springer
Deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity is an inborn
error of purine metabolism associated with uric acid overproduction and a continuum …

Rediscovering the use of chatbots in education: A systematic literature review

…, T Daradoumis, JMM Puig - Computer Applications in …, 2020 - Wiley Online Library
Chatbots have been around for years and have been used in many areas such as medicine
or commerce. Our focus is on the development and current uses of chatbots in the field of …

Uric acid and oxidative stress: relative impact on cardiovascular risk

P Strazzullo, JG Puig - Nutrition, Metabolism and Cardiovascular Diseases, 2007 - Elsevier
… Author links open overlay panel Pasquale Strazzullo a , Juan Garcia Puig b … 1720 M/F J-shaped
relation between SUA and CVD events in multivariate analysis Yes (J-shaped) …

[HTML][HTML] MRI-guided thrombolysis for stroke with unknown time of onset

…, L Neeb, N Perez de la Ossa, J Puig… - … England Journal of …, 2018 - Mass Medical Soc
Background Under current guidelines, intravenous thrombolysis is used to treat acute stroke
only if it can be ascertained that the time since the onset of symptoms was less than 4.5 …

Hydroxychloroquine for early treatment of adults with mild coronavirus disease 2019: a randomized, controlled trial

…, J Puig, C Quiñones, J Reyes-Ureña… - Clinical Infectious …, 2021 - academic.oup.com
Background No effective treatments for coronavirus disease 2019 (COVID-19) exist. We
aimed to determine whether early treatment with hydroxychloroquine (HCQ) would be …

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

…, F Benhamed, V Azalbert, V Blasco-Baque, J Puig… - Nature medicine, 2018 - nature.com
Hepatic steatosis is a multifactorial condition that is often observed in obese patients and is
a prelude to non-alcoholic fatty liver disease. Here, we combine shotgun sequencing of fecal …

[HTML][HTML] Federated learning enables big data for rare cancer boundary detection

…, J Capellades, J Puig, J Trenkler, J Pichler… - Nature …, 2022 - nature.com
Although machine learning (ML) has shown promise across disciplines, out-of-sample
generalizability is concerning. This is currently addressed by sharing multi-site data, but such …

[PDF][PDF] Microbiota alterations in proline metabolism impact depression

…, JM Moreno-Navarrete, J Puig, J Garre-Olmo… - Cell metabolism, 2022 - cell.com
The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with
low treatment efficacy. However, the field is dominated by underpowered studies focusing on …

Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: The NESTOR* study

M Marre, JG Puig, F Kokot, M Fernandez… - Journal of …, 2004 - journals.lww.com
Objectives To test whether microalbuminuria in patients with type 2 diabetes and hypertension
is primarily dependent on the severity of hypertension, and to compare the effectiveness …

[HTML][HTML] A cluster-randomized trial of hydroxychloroquine for prevention of Covid-19

…, S Narejos, A Nieto, N Prat, J Puig… - … England Journal of …, 2021 - Mass Medical Soc
Background Current strategies for preventing severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection are limited to nonpharmacologic interventions. …