User profiles for J Yuan

Junying Yuan

- Verified email at hms.harvard.edu - Cited by 126676

Jianda Yuan MD. Ph.D.

- Verified email at mskcc.org - Cited by 28761

[HTML][HTML] Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

…, HU Simon, P Vandenabeele, E White, J Yuan… - Cell Death & …, 2012 - nature.com
In 2009, the Nomenclature Committee on Cell Death (NCCD) proposed a set of recommendations
for the definition of distinct cell death morphologies and for the appropriate use of cell …

Autophagy in major human diseases

…, N Tavernarakis, SA Tooze, T Yoshimori, J Yuan… - The EMBO …, 2021 - embopress.org
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Caspases in apoptosis and beyond

J Li, J Yuan - Oncogene, 2008 - nature.com
The demonstration of protein sequence and functional homology of the Caenorhabditis
elegans programmed cell death gene product, CED-3, with human caspase-1 in 1993 triggered …

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

…, J Chen, Y Meng, J Wang, Y Lin, J Yuan, Z Xie, J Ma… - The lancet, 2020 - thelancet.com
Background In late December, 2019, patients presenting with viral pneumonia due to an
unidentified microbial agent were reported in Wuhan, China. A novel coronavirus was …

[HTML][HTML] Antibody responses to SARS-CoV-2 in patients with COVID-19

…, F Zhang, P Liu, J Yuan, Q Li, JL Hu, J Chen… - Nature medicine, 2020 - nature.com
We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within
19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G …

[HTML][HTML] Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

…, G Nunez, ME Peter, J Tschopp, J Yuan… - Cell death & …, 2009 - nature.com
Different types of cell death are often defined by morphological criteria, without a clear
reference to precise biochemical mechanisms. The Nomenclature Committee on Cell Death (…

Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

…, P Kvistborg, V Makarov, JJ Havel, W Lee, J Yuan… - Science, 2015 - science.org
Immune checkpoint inhibitors, which unleash a patient’s own T cells to kill tumors, are
revolutionizing cancer treatment. To unravel the genomic determinants of response to this therapy, …

SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler

…, J Yuan, G He, Y Chen, Q Pan, Y Liu, J Tang… - …, 2012 - academic.oup.com
Background There is a rapidly increasing amount of de novo genome assembly using next-generation
sequencing (NGS) short reads; however, several big challenges remain to be …

Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications

MF Yuen, HJ Yuan, DKH Wong, JCH Yuen, WM Wong… - Gut, 2005 - gut.bmj.com
Background: Identifying risk factors for the development of complications of chronic hepatitis
B (CHB) is important for setting up treatment criteria. Aim: To determine risk factors for the …

[HTML][HTML] Genetic basis for clinical response to CTLA-4 blockade in melanoma

…, V Makarov, T Merghoub, J Yuan… - … England Journal of …, 2014 - Mass Medical Soc
Background Immune checkpoint inhibitors are effective cancer treatments, but molecular
determinants of clinical benefit are unknown. Ipilimumab and tremelimumab are antibodies …