[HTML][HTML] Canonical and non-canonical Wnt signaling are simultaneously activated by Wnts in colon cancer cells

…, MT Romero-Avila, JA García-Sáinz… - Cellular signalling, 2020 - Elsevier
The Wnt signaling pathway is a crucial regulator of the intestinal epithelium homeostasis
and is altered in most colon cancers. While the role of aberrant canonical, β-catenin-dependent …

[HTML][HTML] Adrenergic regulation of adipocyte metabolism.

JN Fain, JA Garcĩa-Sáinz - Journal of Lipid Research, 1983 - Elsevier
… Wikberg (7) and Fain and Garcia- SAinz (8) suggested that alphal effects involve turnover
of phosphatidylinositol and elevation of cytosol Ca2+, while alpha2 effects involve inhibition of …

Updates in the function and regulation of α1‐adrenoceptors

J Akinaga, JA GarcíaSáinz… - British journal of …, 2019 - Wiley Online Library
… in cells overexpressing recombinant α 1D - adrenoceptors (García-Sáinz & Torres-Padilla,
1999; Rodríguez-Pérez, Romero-Ávila, Reyes-Cruz, & García-Sáinz, 2009); meanwhile, weak …

Differential phosphorylation, desensitization, and internalization of α1A− adrenoceptors activated by norepinephrine and oxymetazoline

…, R Alcántara-Hernández, JA García-Sáinz… - Molecular …, 2013 - ASPET
Loss of response on repetitive drug exposure (ie, tachyphylaxis) is a particular problem for
the vasoconstrictor effects of medications containing oxymetazoline (OXY), an α1-…

α1-Adrenoceptors: function and phosphorylation

JA Garcı́a-Sáinz, J Vázquez-Prado… - European journal of …, 2000 - Elsevier
This review focuses on α 1 -adrenoceptor phosphorylation and function. Most of what is
currently known is based on studies on the hamster α 1B -adrenoceptor. It is known that agonist …

Assembly and sealing of tight junctions: possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin

MS Balda, L Gonzalez-Mariscal, RG Contreras… - The Journal of …, 1991 - Springer
The making and sealing of a tight junction (TJ) requires cell-cell contacts and Ca 2− , and can
be gauged through the development of transepithelial electrical resistance (TER) and the …

Agonist-induced interactions between angiotensin AT1 and epidermal growth factor receptors

…, A García-Caballero, MP Farshori, JA García-Sáinz… - Molecular …, 2005 - ASPET
In rat hepatic C9 cells, angiotensin II (Ang II)-induced activation of angiotensin type 1 (AT 1 )
receptors (AT 1 -Rs) stimulates extracellular signal-regulated kinase (ERK) 1/2 …

Role of phosphatidylinositol turnover in alpha1 and of adenylate cyclase inhibition in alpha2 effects of catecholamines

JN Fain, JA García-Sáinz - Life Sciences, 1980 - Elsevier
Ligand binding and pharmacological studies have indicated that alpha-adrenergic receptors
can be divided into alpha 1 and alpha 2 . We suggest that alpha 1 receptors mediate those …

α1-Adrenoceptors: subtypes, signaling, and roles in health and disease

JA Garcı́a-Sáinz, J Vázquez-Prado… - Archives of medical …, 1999 - Elsevier
α 1 -Adrenoceptors mediate some of the main actions of the natural catecholamines, adrenaline,
and noradrenaline. They participate in many essential physiological processes, such as …

Phosphorylation and desensitization of the lysophosphatidic acid receptor LPA1

…, A García-Caballero, JA García-Sáinz - Biochemical …, 2005 - portlandpress.com
In C9 cells, LPA (lysophosphatidic acid) induced inositol phosphate production, increased
intracellular calcium concentration and inhibited adenylate cyclase activity. These responses …