To date, apoptosis has been characterized biochemically by the production of 180–200 bp
internucleosomal DNA fragments resulting from the activation of an endonuclease(s). The …

The anti‐apoptotic proteins Bcl‐2 and Bcl‐X L bind and inhibit Beclin‐1, an essential mediator
of autophagy. Here, we demonstrate that this interaction involves a BH3 domain within …

Most of the cytotoxic anticancer drugs in current use have been shown to induce apoptosis in
susceptible cells. The fact that disparate agents, which interact with different targets, induce …

Avoidance of apoptosis is critical for the development and sustained growth of tumours. The
pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but …

Three h after whole-body irradiation (8 Gy) of C57BL × DBA/2 F 1 mice, p53 protein was
expressed strongly in the stem cell compartment of the small intestine but at lower levels in the …

A number of 3-alkyl analogues of the experimental antitumor drug mitozolomide [8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one]
have been screened against …

Investigation of events committing cells to death revealed that a concealed NH 2 -terminal
epitope of the pro-apoptotic protein Bak became exposed in vivo before apoptosis. This …

Beclin 1 has recently been identified as novel BH3-only protein, meaning that it carries one
Bcl-2-homology-3 (BH3) domain. As other BH3-only proteins, Beclin 1 interacts with anti-…

Rapid advances in the molecular characterization of tumors, including complete gene
sequencing of multiple cancers in the Cancer Genome Project, have led to an increased …

Cancers are complex and heterogeneous pathological “organs” in a dynamic interplay with
their host. Models of human cancer in vitro, used in cancer biology and drug discovery, are …