Myeloid-lineage cells accomplish a myriad of homeostatic tasks including the recognition of
pathogens, regulation of the inflammatory milieu, and mediation of tissue repair and …

Long-term cognitive impairment is common in survivors of critical illness. Little is known
about the etiology of this serious complication. We sought to summarize current scientific …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related
neurodegenerative disorders with shared genetic etiologies and overlapping clinical and …

ABCA1 is an ATP-binding cassette protein that transports cellular cholesterol and phospholipids
onto high density lipoproteins (HDL) in plasma. Lack of ABCA1 in humans and mice …

Several heterozygous missense mutations in the triggering receptor expressed on myeloid
cells 2 (TREM2) have recently been linked to risk for a number of neurological disorders …

Neuronal inclusions of poly(GA), a protein unconventionally translated from G 4 C 2 repeat
expansions in C9ORF72, are abundant in patients with frontotemporal dementia (FTD) and …

The major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis is a G
4 C 2 repeat expansion in C9ORF72. Efforts to combat neurodegeneration associated with “…

The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer’s disease,
is abundantly expressed in both the brain and periphery. Here, we present evidence that …

Background The ingestion of a high-fat diet (HFD) and the resulting obese state can exert a
multitude of stressors on the individual including anxiety and cognitive dysfunction. Though …

Spinocerebellar ataxia type 1 (SCA1) is one of several neurodegenerative diseases caused
by expansion of a polyglutamine tract in the disease protein, in this case, ATAXIN-1 (ATXN1)…