Cyclic nucleotides have been the subject of a number of reviews during the past few years.
Major emphasis in most of these has been on cyclic AMP, the first of the 3', 5'-nucleotides …

In this article, we will discuss the pathophysiology of peripheral nerve injury in anaesthetic
practice, including factors which increase the susceptibility of nerves to damage. We will …

The pharmacokinetic properties of a drug comprise the relationship between its absorption,
distribution and inactivation. The passage of drugs across cell membranes is a key part of …

Background Provision of preoperative information can alleviate patients' anxiety. However,
the ideal method of delivering this information is unknown. Video information has been …

The lipolytic potencies of 64 compounds, mostly xanthine derivatives, were determined in
epididymal fat cells. Nine of the compounds of widely varying lipolytic potency were examined …

Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3',5'-monophosphate from
guanosine triphosphate, has been identified in a variety of animal tissues. Conditions were …

Lipid emulsion has been used in the successful treatment of local anaesthetic‐induced
cardiovascular collapse in animals and in two cases of cardiac arrest in humans. Previous …

Background. Hypoxaemia during apnoea develops earlier and progresses faster in children
than in adults. Ethical and practical considerations prevent detailed investigation of the issue…

Background: Based on equivocal clinical data, intravenous antioxidant therapy has been used
for the treatment of severe acute pancreatitis. To date there is no randomised comparison …

Guanosine 3',5'-monophosphate (cyclic GMP) increased the rate of adenosine 3',5'-monophosphate
(cyclic AMP) hydrolysis by phosphodiesterase preparations from several tissues. …