User profiles for J. G. McLarnon
james mclarnonprofessor of pharmacology Verified email at mail.ubc.ca Cited by 6402 |
A leaky blood–brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain
JK Ryu, JG McLarnon - Journal of cellular and molecular …, 2009 - Wiley Online Library
This study has used immunohistochemical examination of tissue obtained from Alzheimer’s
disease (AD) brains and rat hippocampus injected with Aβ 1‐42 peptide to determine effects …
disease (AD) brains and rat hippocampus injected with Aβ 1‐42 peptide to determine effects …
[HTML][HTML] A leaky blood–brain barrier to fibrinogen contributes to oxidative damage in Alzheimer's disease
JG McLarnon - Antioxidants, 2021 - mdpi.com
The intactness of blood–brain barrier (BBB) is compromised in Alzheimer’s disease (AD).
Importantly, evidence suggests that the perturbation and abnormalities appearing in BBB can …
Importantly, evidence suggests that the perturbation and abnormalities appearing in BBB can …
Upregulated Expression of Purinergic P2X7 Receptor in Alzheimer Disease and Amyloid-β Peptide-Treated Microglia and in Peptide-Injected Rat Hippocampus
JG McLarnon, JK Ryu, DG Walker… - … of Neuropathology & …, 2006 - academic.oup.com
The expression of the purinergic receptor subtype P2X 7 R, a nonselective cationic channel
activated by high levels of adenosine triphosphate (ATP), has been studied in adult …
activated by high levels of adenosine triphosphate (ATP), has been studied in adult …
Relevance of Aβ 1-42 intrahippocampal injection as an animal model of inflamed Alzheimer's disease brain
JG McLarnon, JK Ryu - Current Alzheimer Research, 2008 - ingentaconnect.com
… [27] Ryu JK and McLarnon JG. Thalidomide inhibition of perturbed vasculature and glial-derived
tumor necrosis factor-α in an animal model of inflamed Alzheimer’s disease brain. …
tumor necrosis factor-α in an animal model of inflamed Alzheimer’s disease brain. …
[PDF][PDF] Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase
…, J Martinez, TA Milner, JK Ryu, JG McLarnon… - Neuron, 2012 - cell.com
Astrocytes are proposed to participate in brain energy metabolism by supplying substrates to
neurons from their glycogen stores and from glycolysis. However, the molecules involved in …
neurons from their glycogen stores and from glycolysis. However, the molecules involved in …
Purinergic mediated changes in Ca2+ mobilization and functional responses in microglia: Effects of low levels of ATP
JG McLarnon - Journal of neuroscience research, 2005 - Wiley Online Library
Microglia, the immune effector cells of the brain, are stimulated by a diversity of agents to
transiently increase levels of intracellular calcium ([Ca 2+ ]i). Changes in [Ca 2+ ]i induced by …
transiently increase levels of intracellular calcium ([Ca 2+ ]i). Changes in [Ca 2+ ]i induced by …
Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease
…, A Nagai, HB Choi, MC Lee, JG McLarnon… - Neurobiology of …, 2004 - Elsevier
We have investigated the effectiveness of transplantation of human neural stem cells into
adult rat striatum prior to induction of striatal damage with the mitochondrial toxin 3-…
adult rat striatum prior to induction of striatal damage with the mitochondrial toxin 3-…
Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain
We investigated the involvement and roles of the ionotropic purinergic receptor P2X 7 R in
microglia in mediating lipopolysaccharide (LPS)-induced inflammatory responses and …
microglia in mediating lipopolysaccharide (LPS)-induced inflammatory responses and …
Generation and characterization of immortalized human microglial cell lines: expression of cytokines and chemokines
…, E Nakagawa, K Hatori, HB Choi, JG McLarnon… - Neurobiology of …, 2001 - Elsevier
Microglia are a major glial component of the central nervous system (CNS), play a critical
role as resident immunocompetent and phagocytic cells in the CNS, and serve as scavenger …
role as resident immunocompetent and phagocytic cells in the CNS, and serve as scavenger …
Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimer's disease
JK Ryu, JG McLarnon - Neuroreport, 2008 - journals.lww.com
Pharmacological antagonism of the ionotropic purinergic P2X 7 R has been studied for
effects on inflammatory reactivity and neuronal viability in amyloid-β 1–42-injected rat …
effects on inflammatory reactivity and neuronal viability in amyloid-β 1–42-injected rat …