User profiles for J. H. Sheehan
 | Jonathan H. SheehanAssociate Professor, Washington Univ. School of Medicine in St. Louis Verified email at wustl.edu Cited by 2434 |
Practically Useful: What the Rosetta Protein Modeling Suite Can Do for You
The objective of this review is to enable researchers to use the software package Rosetta
for biochemical and biomedicinal studies. We provide a brief review of the six most frequent …
for biochemical and biomedicinal studies. We provide a brief review of the six most frequent …
Protocols for molecular modeling with Rosetta3 and RosettaScripts
Previously, we published an article providing an overview of the Rosetta suite of biomacromolecular
modeling software and a series of step-by-step tutorials [Kaufmann, KW, et al. (2010…
modeling software and a series of step-by-step tutorials [Kaufmann, KW, et al. (2010…
The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy
Bruton’s tyrosine kinase (BTK) mediates B cell signaling and is also present in innate
immune cells but not T cells. BTK propagates B cell receptor (BCR) responses to antigen-…
immune cells but not T cells. BTK propagates B cell receptor (BCR) responses to antigen-…
Small-molecule ligand docking into comparative models with Rosetta
Abstract Structure-based drug design is frequently used to accelerate the development of
small-molecule therapeutics. Although substantial progress has been made in X-ray …
small-molecule therapeutics. Although substantial progress has been made in X-ray …
EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib
Oncogenic EGFR mutations are found in 10% to 35% of lung adenocarcinomas. Such
mutations, which present most commonly as small in-frame deletions in exon 19 or point …
mutations, which present most commonly as small in-frame deletions in exon 19 or point …
EGFR Fusions as Novel Therapeutic Targets in Lung Cancer
…, T Vavalà, A Whiteley, H Chen, Y Yan, JH Sheehan… - Cancer discovery, 2016 - AACR
Here, we report that novel epidermal growth factor receptor (EGFR) gene fusions comprising
the N-terminal of EGFR linked to various fusion partners, most commonly RAD51, are …
the N-terminal of EGFR linked to various fusion partners, most commonly RAD51, are …
Inhibitors of the HIV-1 capsid, a target of opportunity
SK Carnes, JH Sheehan, C Aiken - Current Opinion in HIV and …, 2018 - journals.lww.com
Small molecules that bind to the viral capsid protein can be potent inhibitors of HIV infection.
Capsid-targeting drugs are predicted to exhibit high barriers to viral resistance, and ongoing …
Capsid-targeting drugs are predicted to exhibit high barriers to viral resistance, and ongoing …
An Acquired HER2 T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant–Driven Breast Cancer
AB Hanker, MR Brewer, JH Sheehan, JP Koch… - Cancer discovery, 2017 - AACR
We report a HER2 T798I gatekeeper mutation in a patient with HER2 L869R -mutant breast
cancer with acquired resistance to neratinib. Laboratory studies suggested that HER2 …
cancer with acquired resistance to neratinib. Laboratory studies suggested that HER2 …
[PDF][PDF] Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity
…, A Servetto, MR Brewer, JP Koch, JH Sheehan… - Cancer cell, 2021 - cell.com
Activating mutations in HER2 (ERBB2) drive the growth of a subset of breast and other cancers
and tend to co-occur with HER3 (ERBB3) missense mutations. The HER2 tyrosine kinase …
and tend to co-occur with HER3 (ERBB3) missense mutations. The HER2 tyrosine kinase …
NFI transcription factors interact with FOXA1 to regulate prostate-specific gene expression
Androgen receptor (AR) action throughout prostate development and in maintenance of the
prostatic epithelium is partly controlled by interactions between AR and forkhead box (FOX) …
prostatic epithelium is partly controlled by interactions between AR and forkhead box (FOX) …