Motor neuronal disorders, such as the loss of spinal cord motor neurons in amyotrophic
lateral sclerosis or the degeneration of spinal cord motor neuron axons in certain peripheral …

Tramadol hydrochloride produced dose-related antinociception in mouse abdominal constriction
[ED50 = 1.9 (1.2-2.6) mg/kg ip], hot-plate [48 degrees C, ED50 = 21.4 (18.4-25.3) mg/kg …

The explanation for the co-existence of opioid and nonopioid components of tramadol-induced
antinociception appears to be related to the different, but complementary and interactive, …

Topiramate [TPM, 2,3:4,5‐his‐O‐(1‐methyl‐ethylidene)‐β‐D‐fructopyranose sulfamate] (RWJ‐17021‐000,
formerly McN‐4853) is a structurally novel antiepileptic drug (AED). The …

Clioquinol, a metal chelator, has been used for many years as an antimicrobial agent and
more recently as a potential treatment for Alzheimer's disease. Because it binds copper and …

CEP-1347 (KT7515) promotes neuronal survival at dosages that inhibit activation of the c-Jun
amino-terminal kinases (JNKs) in primary embryonic cultures and differentiated PC12 …

Although the mechanism of neuronal death in Alzheimer's disease (AD) has yet to be
elucidated, a putative role for c‐jun in this process has emerged. Thus, it was of interest to …

“Der Nachweis der substanz P in den dorsalen Wurzeln sowie inhre weitgehende Ahnlichkeit
mit der Erregungssubstanz sensibler Nerven' lassen ihre Bedeutung als Ubertragerstoff …

We have explored the structure−activity relationship (SAR) surrounding the clinically
efficacious antiepileptic drug topiramate (1), a unique sugar sulfamate anticonvulsant that was …

The opioid receptors involved in the supraspinal and spinal actions of [D-Pen2, D-Pen5]enkephalin
(DPDPE) for production and/or modulation of analgesia were investigated in two …