[PDF][PDF] Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction.

JD Alvaro, JB Tatro, JM Quillan, M Fogliano… - Molecular …, 1996 - researchgate.net
Melanocortin peptides are reported to antagonize opiate de-pendence and tolerance, but the
neural substrates underlying these actions are unknown. In this study, we characterize the …

[HTML][HTML] Calmodulin binding to G protein-coupling domain of opioid receptors

D Wang, W Sadée, JM Quillan - Journal of Biological Chemistry, 1999 - ASBMB
The ubiquitous intracellular Ca 2+ sensor calmodulin (CaM) regulates numerous proteins
involved in cellular signaling of G protein-coupled receptors, but most known interactions …

Functional screening of G protein–coupled receptors by measuring intracellular calcium with a fluorescence microplate reader

…, B Höfgen, J Lehmann, N Eckstein, JM Quillan… - SLAS Discovery, 2002 - Elsevier
Ligand binding studies reveal information about affinity to G protein—coupled receptors (GPCRs)
rather than functional properties. Increase in intracellular Ca 2+ appears to represent a …

[HTML][HTML] A synthetic human Agouti-related protein-(83–132)-NH2 fragment is a potent inhibitor of melanocortin receptor function

JM Quillan, W Sadée, ET Wei, C Jimenez, L Ji… - FEBS letters, 1998 - Elsevier
Chemical synthesis of Agouti proteins – Agouti and Agouti-related proteins – is complicated
by their large size and by multiple cysteine residues located in the carboxyl terminal regions. …

Inhibition of mouse melanoma cell proliferation by corticotropin-releasing hormone and its analogs.

…, VA Filov, VV Rezsova, A Slominski, JM Quillan - Anticancer …, 2001 - europepmc.org
Background Observations that epidermal cells release both corticotropin-releasing
hormone (CRH) and proopiome lanocortin (POMC) peptides has raised questions about the …

[HTML][HTML] Single nucleotide polymorphisms in the human μ opioid receptor gene alter basal G protein coupling and calmodulin binding

D Wang, JM Quillan, K Winans, JL Lucas… - Journal of Biological …, 2001 - ASBMB
The μ opioid receptor (MOR) plays a central role in mediating acute and chronic effects of
narcotic drugs. Three rare single nucleotide polymorphisms in the hMORgene have been …

Creation and functional screening of a multi-use peptide library.

…, GF Graminski, JM Quillan… - Proceedings of the …, 1994 - National Acad Sciences
Studies of functional interactions between transmembrane proteins such as G-protein-coupled
receptors and ligands would benefit from the ability to utilize synthetic molecule libraries. …

Discovery and structure-function analysis of alpha-melanocyte-stimulating hormone antagonists.

CK Jayawickreme, JM Quillan, GF Graminski… - Journal of Biological …, 1994 - Elsevier
Structure-function relationships of alpha-melanocyte-stimulating hormone (alpha-MSH,
alpha-melanotropin) were investigated and novel alpha-MSH receptor antagonists were …

Dynorphin peptides: antagonists of melanocortin receptors

JM Quillan, W Sadée - Pharmaceutical research, 1997 - Springer
Purpose. To identify possible targets that mediate the non-opioid effects of dynorphin A (DynA),
effects that include inflammation and aggravation of traumatic nerve injury. Methods. We …

Combinatorial diffusion assay used to identify topically active melanocyte-stimulating hormone receptor antagonists.

JM Quillan, CK Jayawickreme… - Proceedings of the …, 1995 - National Acad Sciences
alpha-Melanocyte-stimulating hormone (alpha-MSH) is implicated in pigmentation, central
nervous system and immune system functions, growth, mitogenesis, and melanoma. …