Neurosteroids are endogenous modulators of neuronal excitability and nervous system
development and are being developed as anesthetic agents and treatments for psychiatric …

Neuroactive steroids modulate the function of γ-aminobutyric acid, type A (GABA A ) receptors
in the central nervous system by an unknown mechanism. In this study we have used a …

The effects of neuroactive steroids on the function of GABA A receptors were studied using
cell‐attached records of single channel activity recorded from HEK293 cells transfected with …

This study examines how site-specific binding to three identified neurosteroid-binding sites
in the α 1 β 3 GABA A receptor (GABA A R) contributes to neurosteroid allosteric modulation. …

Neurosteroids are endogenous sterols that potentiate or inhibit pentameric ligand-gated ion
channels (pLGICs) and can be effective anesthetics, analgesics, or anti-epileptic drugs. The …

Cholesterol is an essential component of cell membranes, and is required for mammalian
pentameric ligand-gated ion channel (pLGIC) function. Computational studies suggest direct …

The microsatellite instability that is a feature of tumors in patients with hereditary nonpolyposis
colorectal cancer (HNPCC) is a consequence of defective DNA mismatch repair. …

Neuroactive steroids modulate the function of γ-aminobutyric acid type A (GABA A ) receptors
in brain; this is the presumed basis of their action as anesthetics. In a previous study using …

Neurosteroids positively modulate GABA-A receptor (GABA A R) channel activity by binding
to a transmembrane domain intersubunit site. Understanding the interactions in this site that …

A neurosteroid potentiation site can be moved among GABAA receptor subunits - Bracamontes
- 2012 - The Journal of Physiology - Wiley Online Library … Bracamontes… Bracamontes …