User profiles for J. R. Idle
Jeffrey R IdleWestern New England University Cited by 24853 |
LC-MS-based metabolomics in drug metabolism
Xenobiotic metabolism, a ubiquitous natural response to foreign compounds, elicits initiating
signals for many pathophysiological events. Currently, most widely used techniques for …
signals for many pathophysiological events. Currently, most widely used techniques for …
Xenobiotic metabolomics: major impact on the metabolome
Xenobiotics are encountered by humans on a daily basis and include drugs, environmental
pollutants, cosmetics, and even components of the diet. These chemicals undergo …
pollutants, cosmetics, and even components of the diet. These chemicals undergo …
The metabolomic window into hepatobiliary disease
The emergent discipline of metabolomics has attracted considerable research effort in
hepatology. Here we review the metabolomic data for non-alcoholic fatty liver disease (NAFLD), …
hepatology. Here we review the metabolomic data for non-alcoholic fatty liver disease (NAFLD), …
Polymorphic hydroxylation of debrisoquine in man
Debrisoquine and its primary metabolite, 4-hydroxydebrisoquine, were measured in the
urine of 94 volunteers after a single oral dose of 10 mg debrisoquine. The ratio between …
urine of 94 volunteers after a single oral dose of 10 mg debrisoquine. The ratio between …
Nomenclature for human CYP2D6 alleles
…, FJ Gonzalez, JD Huang, JR Idle… - Pharmacogenetics …, 1996 - journals.lww.com
To standardize CYP2D6 allele nomenclature, and to conform with international human gene
nomenclature guidelines, an alternative to the current arbitrary system is described. Based …
nomenclature guidelines, an alternative to the current arbitrary system is described. Based …
Metabolism of melatonin by human cytochromes p450
X Ma, JR Idle, KW Krausz, FJ Gonzalez - Drug metabolism and disposition, 2005 - ASPET
In humans, the pineal hormone melatonin (MEL) is principally metabolized to 6-hydroxymelatonin
(6-HMEL), which is further conjugated with sulfate and excreted in urine. MEL O-…
(6-HMEL), which is further conjugated with sulfate and excreted in urine. MEL O-…
The incidence and severity of nifedipine‐induced gingival overgrowth
S Barclay, JM Thomason, JR Idle… - Journal of clinical …, 1992 - Wiley Online Library
The gingival health of 19 patients with cardiovascular problems who were medicated with
nifedipine was compared with a similar cohort treated with atenolol and a control group of …
nifedipine was compared with a similar cohort treated with atenolol and a control group of …
[PDF][PDF] Metabolomics
JR Idle, FJ Gonzalez - Cell metabolism, 2007 - cell.com
Metabolomics is the systematic identification and quantitation of all metabolites in a given
organism or biological sample. The enhanced resolution provided by nuclear magnetic …
organism or biological sample. The enhanced resolution provided by nuclear magnetic …
Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling
There has been limited analysis of the effects of hepatocellular carcinoma (HCC) on liver
metabolism and circulating endogenous metabolites. Here, we report the findings of a plasma …
metabolism and circulating endogenous metabolites. Here, we report the findings of a plasma …
Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy
…, H Taber, A Steward, FJ Gonzalez, JR Idle - Pharmacogenetics …, 1995 - journals.lww.com
… However the list of CYP2C9 drug substrates has been documented (Gonzalez & Idle, 1994)
… Gonzalez FJ, Idle JR. Pharmacogenetic phenotyping and genotyping: present status and …
… Gonzalez FJ, Idle JR. Pharmacogenetic phenotyping and genotyping: present status and …