Xenobiotic metabolism, a ubiquitous natural response to foreign compounds, elicits initiating
signals for many pathophysiological events. Currently, most widely used techniques for …

Xenobiotics are encountered by humans on a daily basis and include drugs, environmental
pollutants, cosmetics, and even components of the diet. These chemicals undergo …

The emergent discipline of metabolomics has attracted considerable research effort in
hepatology. Here we review the metabolomic data for non-alcoholic fatty liver disease (NAFLD), …

Debrisoquine and its primary metabolite, 4-hydroxydebrisoquine, were measured in the
urine of 94 volunteers after a single oral dose of 10 mg debrisoquine. The ratio between …

To standardize CYP2D6 allele nomenclature, and to conform with international human gene
nomenclature guidelines, an alternative to the current arbitrary system is described. Based …

In humans, the pineal hormone melatonin (MEL) is principally metabolized to 6-hydroxymelatonin
(6-HMEL), which is further conjugated with sulfate and excreted in urine. MEL O-…

The gingival health of 19 patients with cardiovascular problems who were medicated with
nifedipine was compared with a similar cohort treated with atenolol and a control group of …

Metabolomics is the systematic identification and quantitation of all metabolites in a given
organism or biological sample. The enhanced resolution provided by nuclear magnetic …

There has been limited analysis of the effects of hepatocellular carcinoma (HCC) on liver
metabolism and circulating endogenous metabolites. Here, we report the findings of a plasma …

… However the list of CYP2C9 drug substrates has been documented (Gonzalez & Idle, 1994)
… Gonzalez FJ, Idle JR. Pharmacogenetic phenotyping and genotyping: present status and …