User profiles for J. W. REGAN
John W. ReganProfessor of Pharmacology and Toxicology, University of Arizona Verified email at pharmacy.arizona.edu Cited by 14329 |
Chimeric α2-,β2-Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity
BK Kobilka, TS Kobilka, K Daniel, JW Regan… - Science, 1988 - science.org
The α 2 and β 2 adrenergic receptors, both of which are activated by epinephrine, but which
can be differentiated by selective drugs, have opposite effects (inhibitory and stimulatory) on …
can be differentiated by selective drugs, have opposite effects (inhibitory and stimulatory) on …
EP2 and EP4 prostanoid receptor signaling
JW Regan - Life sciences, 2003 - Elsevier
… We have recently proposed a mechanism (Fujino and Regan, 2003) that could explain how the
EP 4 receptor could induce the expression of … Fujino and Regan, 2003 … Fujino, JW Regan …
EP 4 receptor could induce the expression of … Fujino and Regan, 2003 … Fujino, JW Regan …
Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α2-Adrenergic Receptor
The gene for the human platelet α 2 -adrenergic receptor has been cloned with oligonucleotides
corresponding to the partial amino acid sequence of the purified receptor. The identity …
corresponding to the partial amino acid sequence of the purified receptor. The identity …
[HTML][HTML] Enzymes and Receptors of Prostaglandin Pathways with Arachidonic Acid-derived Versus Eicosapentaenoic Acid-derived Substrates and Products*♦
Dietary fish oil containing ω3 highly unsaturated fatty acids has cardioprotective and anti-inflammatory
effects. Prostaglandins (PGs) and thromboxanes are produced in vivo both from …
effects. Prostaglandins (PGs) and thromboxanes are produced in vivo both from …
Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype.
JW Regan, TJ Bailey, DJ Pepperl, KL Pierce… - Molecular …, 1994 - ASPET
A cDNA that when expressed has the binding and functional characteristics of the pharmacologically
defined EP2 prostaglandin (PG) receptor [Cardiovasc. Drug Rev. 11:165-179 (1993…
defined EP2 prostaglandin (PG) receptor [Cardiovasc. Drug Rev. 11:165-179 (1993…
[HTML][HTML] Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by …
H Fujino, KA West, JW Regan - Journal of Biological Chemistry, 2002 - ASBMB
Recently we have shown that the FP B prostanoid receptor, a G-protein-coupled receptor
that couples to Gα q , activates T-cell factor (Tcf)/lymphoid enhancer factor (Lef)-mediated …
that couples to Gα q , activates T-cell factor (Tcf)/lymphoid enhancer factor (Lef)-mediated …
[HTML][HTML] Prostaglandin E2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the phosphatidylinositol 3 …
H Fujino, W Xu, JW Regan - Journal of Biological Chemistry, 2003 - ASBMB
Prostaglandin E 2 (PGE 2 ) mediates its physiological effects by interactions with a subfamily
of G-protein-coupled receptors known as EP receptors. These receptors consist of four …
of G-protein-coupled receptors known as EP receptors. These receptors consist of four …
Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.
JW Regan, TS Kobilka, TL Yang-Feng… - Proceedings of the …, 1988 - National Acad Sciences
An alpha 2-adrenergic receptor subtype has been cloned from a human kidney cDNA
library using the gene for the human platelet alpha 2-adrenergic receptor as a probe. The …
library using the gene for the human platelet alpha 2-adrenergic receptor as a probe. The …
Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.
BF O'Dowd, M Hnatowich, JW Regan… - Journal of Biological …, 1988 - ASBMB
Numerous plasma membrane-bound receptors are coupled to various effectors via a family
of guanine nucleotide regulatory proteins (G proteins). Amino acid sequences of these …
of guanine nucleotide regulatory proteins (G proteins). Amino acid sequences of these …
[HTML][HTML] Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase
Recent evidence suggests that many signaling molecules localize in microdomains of the
plasma membrane, particularly caveolae. In this study, overexpression of adenylyl cyclase …
plasma membrane, particularly caveolae. In this study, overexpression of adenylyl cyclase …