[HTML][HTML] Diagnostic utility of exome sequencing for kidney disease

…, S Sanna-Cherchi, K Kiryluk, J Fleckner… - … England Journal of …, 2019 - Mass Medical Soc
Background Exome sequencing is emerging as a first-line diagnostic method in some clinical
disciplines, but its usefulness has yet to be examined for most constitutional disorders in …

The ATLAS level-1 calorimeter trigger

…, J Fleckner, F Föhlisch, J Garvey… - Journal of …, 2008 - iopscience.iop.org
The ATLAS Level-1 Calorimeter Trigger uses reduced-granularity information from all the
ATLAS calorimeters to search for high transverse-energy electrons, photons, τ leptons and jets, …

U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction.

J Fleckner, M Zhang, J Valcarcel… - Genes & …, 1997 - genesdev.cshlp.org
Splicing of mRNA precursors (pre-mRNAs) comprises a series of ATP-dependent steps, the
first of which is the stable binding of U2 snRNP at the pre-mRNA branchpoint. The basis of …

Artifactual insulin release from differentiated embryonic stem cells

…, RS Heller, J Håkansson, J Fleckner… - Diabetes, 2004 - Am Diabetes Assoc
Several recent reports claim the generation of insulin-producing cells from embryonic stem
cells via the differentiation of progenitors that express nestin. Here, we investigate further the …

Distinct developmental profile of lower-body adipose tissue defines resistance against obesity-associated metabolic complications

…, N Denton, JL Min, KT Zondervan, J Fleckner… - Diabetes, 2014 - Am Diabetes Assoc
Upper- and lower-body fat depots exhibit opposing associations with obesity-related metabolic
disease. We defined the relationship between DEXA-quantified fat depots and diabetes/…

Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process

…, P Hallenborg, L Pridal, J Fleckner… - Biochemical …, 2003 - portlandpress.com
Adipocytes play a central role in whole-body energy homoeostasis. Complex regulatory
transcriptional networks control adipogensis, with ligand-dependent activation of PPARγ (…

Novel tricyclic-α-alkyloxyphenylpropionic acids: dual PPARα/γ agonists with hypolipidemic and antidiabetic activity

…, J Sturis, HF Wöldike, J Fleckner… - Journal of medicinal …, 2002 - ACS Publications
Synthesis and structure−activity relationships of tricyclic α-ethoxy-phenylpropionic acid
derivatives guided by in vitro PPARα and PPARγ transactivation data and computer modeling led …

[HTML][HTML] Transcriptional program induced by factor VIIa‐tissue factor, PAR1 and PAR2 in MDA‐MB‐231 cells

…, BB Sørensen, GM Hjortø, J Fleckner… - Journal of thrombosis …, 2007 - Elsevier
J. Fleckner contributed vital new analytical tools (cDNA microarrays). LVM Rao designed
research, analyzed data and wrote the paper. LC Petersen designed research, performed …

[HTML][HTML] Hepatocyte mARC1 promotes fatty liver disease

…, WG Haynes, NW Pursell, K Coppieters, J Fleckner… - JHEP Reports, 2023 - Elsevier
Background & Aims Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25%
worldwide, with significant public health consequences yet few effective treatments. Human …

Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor α/γ agonist ragaglitazar

…, SB Mortensen, J Fleckner… - Journal of Medicinal …, 2003 - ACS Publications
A new and improved synthesis of the peroxisome proliferator-activated receptor (PPAR) agonist
ragaglitazar applicable for large-scale preparation has been developed. The convergent …