Transforming growth factor β1 (TGF-β1) is a potent fibrotic factor responsible for the
synthesis of extracellular matrix. TGF-β1 acts through the TGF-β type I and type II receptors to …

1 Long chain fatty acids have recently been identified as agonists for the G protein‐coupled
receptors GPR40 and GPR120. Here, we present the first description of GW9508, a small‐…

Screening of our internal compound collection for inhibitors of the transforming growth factor
β1 (TGF-β1) type I receptor (ALK5) identified several hits. Optimization of the …

The CD4 molecule is a T cell surface glycoprotein that interacts with high affinity with the
envelope glycoprotein of the human immunodeficiency virus, HIV, thus serving as a cellular …

Entry into mitosis by mammalian cells is triggered by the activation of the cdc2/cyclin B
holoenzyme. This is accomplished by the specific dephosphorylation of key residues by the …

Eotaxin has been found to bind exclusively to a single chemokine receptor, CCR3. Using
expression sequence tag screening of an activated monocyte library, a second chemokine has …

Eosinophils have been implicated in the pathogenesis of asthma and other allergic diseases.
Several CC chemokines including eotaxin (CCL-11), eotaxin-2 (CCL-24), RANTES (CCL-5…

With completion of the sequencing of the human and mouse genomes, the primary
sequences of close to 400 non-olfactory G protein–coupled receptors (GPCRs) have been …

Galactose utilization in Streptomyces lividans was shown to be controlled by an operon that
is induced in the presence of galactose and repressed by glucose. Two promoters, galP1 …

Several drugs and related compounds which are secondary and tertiary amines were tested
for mutagenicity with the Ames Salmonella/mammalian-microsome mutagenicity test, as …