Selective modulation of α7 nicotinic acetylcholine receptors (nAChRs) is thought to regulate
processes impaired in schizophrenia, Alzheimer's disease, and other dementias. One …

Augmentation of nicotinic α7 receptor function is considered to be a potential therapeutic
strategy aimed at ameliorating cognitive and mnemonic dysfunction in relation to debilitating …

The α7 nicotinic acetylcholine receptor (nAChR) plays an important role in cognitive processes
and may represent a drug target for treating cognitive deficits in neurodegenerative and …

Background and purpose: Several agonists of the α7 nicotinic acetylcholine receptor (nAChR)
have been developed for treatment of cognitive deficits. However, agonist efficacy in vivo …

Targeting α7 neuronal acetylcholine receptors (nAChRs) with selective agonists and positive
allosteric modulators (PAMs) is considered a therapeutic approach for managing cognitive …

Among the diverse sets of nicotinic acetylcholine receptors (nAChRs), the α7 subtype is
highly expressed in the hippocampus and cortex and is thought to play important roles in a …

The discovery of a series of pyrrole-sulfonamides as positive allosteric modulators (PAM) of
α7 nAChRs is described. Optimization of this series led to the identification of 19 (A-867744), …

α4β2 neuronal nicotinic receptors (nAChRs) can exist in high and low sensitivity states
possibly due to distinct stoichiometries during subunit assembly: (α4) 2 (β2) 3 pentamer (high …

Genistein and 5-hydroxyindole (5-HI) potentiate the α7 nicotinic acetylcholine receptor
current by primarily increasing peak amplitude, a property of type I α7 positive allosteric …

α3-Containing (α3*) and α7 nicotinic acetylcholine receptors (nAChRs) are expressed in
human IMR-32 neuroblastoma cells and implicated in Ca 2+ signaling. In this study, we …