Comparison of the Pharmacological Properties of Rat NaV1.8 with Rat NaV1.2a and Human NaV1.5 Voltage-Gated Sodium Channel Subtypes Using a Membrane Potential …

…, N Mai, E Kaufman, J Martin, J Hembrador… - Receptors and …, 2004 - Taylor & Francis
A novel, membrane potential sensitive dye and a fluorescence imaging plate reader (FLIPR
R ) have been used to characterize the pharmacological properties of rat Na v 1.8 voltage-…

Evidence for a multivalent interaction of symmetrical, N-linked, lidocaine dimers with voltage-gated Na+ channels

JAM Smith, SM Amagasu, J Hembrador, S Axt… - Molecular …, 2006 - ASPET
The interaction of symmetrical lidocaine dimers with voltage-gated Na + channels (VGSCs)
was examined using a FLIPR membrane potential assay and voltage-clamp. The dimers, in …

18F-4V for PET–CT Imaging of VCAM-1 Expression in Atherosclerosis

…, E Keliher, P Panizzi, H Zhang, S Hembrador… - JACC: Cardiovascular …, 2009 - jacc.org
Objectives : The aim of this study was to iteratively develop and validate an 18 F-labeled small
vascular cell adhesion molecule (VCAM)-1 affinity ligand and demonstrate the feasibility …

Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis C

D Butera, S Marukian, AE Iwamaye, E Hembrador… - Blood, 2005 - ashpublications.org
Chronic infection with the hepatitis C virus (HCV) is associated with failures of T-cell–mediated
immune clearance and with abnormal B-cell growth and activation. We examined the …

A multicenter randomized trial of a checklist for endotracheal intubation of critically ill adults

…, RM Brown, WH Self, E Long, S Hembrador… - Chest, 2018 - Elsevier
Background Hypoxemia and hypotension are common complications during endotracheal
intubation of critically ill adults. Verbal performance of a written, preintubation checklist may …

[PDF][PDF] The inhibitory receptor NKG2A sustains virus-specific CD8+ T cells in response to a lethal poxvirus infection

AS Rapaport, J Schriewer, S Gilfillan, E Hembrador… - Immunity, 2015 - cell.com
CD8 + T cells and NK cells protect from viral infections by killing virally infected cells and
secreting interferon-γ. Several inhibitory receptors limit the magnitude and duration of these anti…

Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox–an animal model of smallpox

S Parker, NG Chen, S Foster, H Hartzler, E Hembrador… - Antiviral research, 2012 - Elsevier
The human population is currently faced with the potential use of natural or recombinant
variola and monkeypox viruses as biological weapons. Furthermore, the emergence of human …

Quasispecies heterogeneity within the E1/E2 region as a pretreatment variable during pegylated interferon therapy of chronic hepatitis C virus infection

TJ Chambers, X Fan, DA Droll, E Hembrador… - Journal of …, 2005 - Am Soc Microbiol
A series of 29 patients undergoing treatment for chronic hepatitis C virus (HCV) genotype 1
infection with pegylated alpha-2a interferon plus ribavirin were studied for patterns of …

Detection of pulse trains in the electrically stimulated cochlea: Effects of cochlear health

BE Pfingst, DJ Colesa, S Hembrador… - The Journal of the …, 2011 - pubs.aip.org
Perception of electrical stimuli varies widely across users of cochlear implants and across
stimulation sites in individual users. It is commonly assumed that the ability of subjects to …

[HTML][HTML] Mousepox in the C57BL/6 strain provides an improved model for evaluating anti-poxvirus therapies

S Parker, AM Siddiqui, C Oberle, E Hembrador… - Virology, 2009 - Elsevier
The intranasal lethal mousepox model employing the A/Ncr mouse strain is used to evaluate
anti-orthopoxvirus therapies. These infections mimic large droplet transmission and result …