User profiles for J. Nunan

Dr Jordan Nunan

Senior Lecturer, University of Northampton
Verified email at northampton.ac.uk
Cited by 118

[HTML][HTML] Regulation of APP cleavage by α-, β-and γ-secretases

J Nunan, DH Small - FEBS letters, 2000 - Elsevier
Proteolytic cleavage of the amyloid protein from the amyloid protein precursor (APP) by APP
secretases is a key event in Alzheimer’s disease (AD) pathogenesis. α-Secretases cleave …

[HTML][HTML] Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1

…, BJ Turner, D Tomas, JA Lysaght, J Nunan… - Journal of Biological …, 2006 - ASBMB
Mutations in Cu/Zn superoxide dismutase (SOD1) are linked to motor neuron death in familial
amyotrophic lateral sclerosis (ALS) by an unclear mechanism, although misfolded SOD1 …

Physicochemical properties of Ce-containing three-way catalysts and the effect of Ce on catalyst activity

JG Nunan, HJ Robota, MJ Cohn, SA Bradley - Journal of Catalysis, 1992 - Elsevier
The activity of Pt,Rh,Ce/γ-Al 2 O 3 and Pt,Rh/CeO 2 catalysts has been studied in a full
complement synthetic exhaust gas mixture consisting of H 2 , CO, C 3 H 6 , C 3 H 8 , NO, O 2 , N 2 …

Higher alcohol and oxygenate synthesis over cesium-doped CuZno catalysts

JG Nunan, CE Bogdan, K Klier, KJ Smith, CW Young… - Journal of …, 1989 - Elsevier
The synthesis of higher (C + 2 ) alcohols and esters has been studied over cesium-doped
Cu ZnO catalysts. Under higher alcohol synthesis conditions, eg, 583 K, 7.6 MPa, and gas …

The C‐terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome‐dependent mechanism distinct from γ‐secretase

J Nunan, MS Shearman, F Checler… - European Journal of …, 2001 - Wiley Online Library
The β‐amyloid protein (Aβ) is derived by proteolytic processing of the amyloid protein
precursor (APP). Cleavage of APP by β‐secretase generates a C‐terminal fragment (APP‐CTFβ), …

Methanol and C2 oxygenate synthesis over cesium doped CuZnO and Cu/ZnO/Al2O3 catalysts: A study of selectivity and 13C incorporation patterns

JG Nunan, CE Bogdan, K Klier, KJ Smith, CW Young… - Journal of …, 1988 - Elsevier
Cesium formate significantly promotes methanol and C 2 oxygenate (methyl formate MF and
ethanol EtOH) synthesis over the Cu ZnO catalyst. C NMR analysis of the product obtained …

Corticotropin-releasing factor increases GABA synaptic activity and induces inward current in 5-hydroxytryptamine dorsal raphe neurons

…, E Freeman-Daniels, JC Lemos, JD Nunan… - Journal of …, 2008 - Soc Neuroscience
Stress-related psychiatric disorders such as anxiety and depression involve dysfunction of the
serotonin [5-hydroxytryptamine (5-HT)] system. Previous studies have found that the stress …

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

J Nunan, DH Small - Essays in Biochemistry, 2002 - portlandpress.com
The proteolytic processing of the amyloid-beta protein precursor plays a key role in the
development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur …

Proteasome‐mediated degradation of the C‐terminus of the Alzheimer's disease β‐amyloid protein precursor: Effect of C‐terminal truncation on production of β …

J Nunan, NA Williamson, AF Hill… - Journal of …, 2003 - Wiley Online Library
The β‐amyloid protein (Aβ) is derived by proteolytic processing of the amyloid protein
precursor (APP). Cleavage of APP by β‐secretase generates a C‐terminal fragment (APP‐CTFβ), …

[PDF][PDF] Triage Into the Community for COVID-19 (TICC-19) Patients Pathway-Service evaluation of the virtual monitoring of patients with COVID pneumonia

J Nunan, D Clarke, A Malakouti, D Tannetta… - Acute Med, 2020 - researchgate.net
… Lead by Dr Andy Walden and Dr Joseph Nunan. • A virtual clinic where by the clinical
team at RBH contact … The N Engl J Med. 2020; 382(8): 727–33. doi: 10.1056/NEJMoa2001017. …