User profiles for J. Passas
Joao PassosProfessor, Mayo Clinic, MN, USA Verified email at mayo.edu Cited by 30452 |
[PDF][PDF] Vygotsky eo desenvolvimento humano
ET RABELLO, JS Passos - Portal Brasileiro de Análise Transacional, 2010 - academia.edu
… Para J. Piaget, dentro da reflexão construtivista sobre desenvolvimento e aprendizagem,
tais conceitos se inter-relacionam, sendo a aprendizagem a alavanca do desenvolvimento. A …
tais conceitos se inter-relacionam, sendo a aprendizagem a alavanca do desenvolvimento. A …
[PDF][PDF] Cellular senescence: defining a path forward
…, JF Passos, PD Robbins, CA Schmitt, J Sedivy… - Cell, 2019 - cell.com
Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …
[HTML][HTML] Telomere dysfunction in ageing and age-related diseases
Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction.
Telomere shortening and damage are recognized causes of cellular senescence and …
Telomere shortening and damage are recognized causes of cellular senescence and …
[HTML][HTML] Stress, cell senescence and organismal ageing
JP de Magalhães, JF Passos - Mechanisms of ageing and development, 2018 - Elsevier
Cellular senescence was first described by Hayflick and Moorhead in the 1960s as the
irreversible arrest of cells following prolonged cultivation. Telomere shortening is the key …
irreversible arrest of cells following prolonged cultivation. Telomere shortening is the key …
[HTML][HTML] Cellular senescence mediates fibrotic pulmonary disease
…, T Tchkonia, PD Robbins, MC Aubry, JF Passos… - Nature …, 2017 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling,
leading to compromised lung function. Cellular senescence markers are detectable within …
leading to compromised lung function. Cellular senescence markers are detectable within …
[HTML][HTML] Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
…, LO Lerman, KM McDonald, TJ McKenzie, JF Passos… - …, 2019 - thelancet.com
Background Senescent cells, which can release factors that cause inflammation and dysfunction,
the senescence-associated secretory phenotype (SASP), accumulate with ageing and …
the senescence-associated secretory phenotype (SASP), accumulate with ageing and …
[HTML][HTML] A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Although cellular senescence drives multiple age-related co-morbidities through the
senescence-associated secretory phenotype, in vivo senescent cell identification remains …
senescence-associated secretory phenotype, in vivo senescent cell identification remains …
[HTML][HTML] Cellular senescence drives age-dependent hepatic steatosis
… RNA-ISH for (h,i) p16 and (j,k) eGFP shows a significant increase in p16- and eGFP-positive
hepatocytes in HF-fed mice and a significant decrease after treatment with AP20187. (i,k) …
hepatocytes in HF-fed mice and a significant decrease after treatment with AP20187. (i,k) …
Feedback between p21 and reactive oxygen production is necessary for cell senescence
Cellular senescence—the permanent arrest of cycling in normally proliferating cells such as
fibroblasts—contributes both to age‐related loss of mammalian tissue homeostasis and acts …
fibroblasts—contributes both to age‐related loss of mammalian tissue homeostasis and acts …
[HTML][HTML] Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
Telomeres are specialized nucleoprotein structures, which protect chromosome ends and
have been implicated in the ageing process. Telomere shortening has been shown to …
have been implicated in the ageing process. Telomere shortening has been shown to …