c-Jun amino-terminal kinases (JNKs) and mitogen-activatedprotein kinases (MAPKs) are
closely related; however, they are independently regulated by a variety of environmental stimuli…

CERAMIDE is an important regulatory participant of programmed cell death (apoptosis) induced
by tumour-necrosis factor (TNF)-α and Fas ligand, members of the TNF superfamily 1–6 …

G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved
in signal transmission, have recently emerged as crucial players in tumour growth and …

G-protein-coupled receptors (GPCRs) constitute the largest family of cell-surface molecules
involved in signal transmission. These receptors play key physiological roles and their …

Integrin receptors play important roles in organizing the actin-containing cytoskeleton and in
signal transduction from the extracellular matrix. The initial steps in integrin function can be …

How vascular endothelial growth factor (VEGF) induces vascular permeability, its first described
function, remains poorly understood. Here, we provide evidence of a novel signalling …

How cyclooxygenase-2 (COX-2) and its proinflammatory metabolite prostaglandin E2 (PGE2)
enhance colon cancer progression remains poorly understood. We show that PGE2 …

MITOGEN-ACTIVATED protein kinases, MAP kinases or ERKs (extracellular signal-regulated
kinases) are rapidly stimulated by growth-promoting factors acting on a variety of cell-…

Carbon nanotube-based drug delivery holds great promise for cancer therapy. Herein we
report the first targeted, in vivo killing of cancer cells using a drug-single wall carbon nanotube (…

Receptors coupled to heterotrimeric GTP-binding proteins (G proteins) are integral membrane
proteins involved in the transmission of signals from the extracellular environment to the …