Objective In 2003, critical care and infectious disease experts representing 11 international
organizations developed management guidelines for severe sepsis and septic shock that …

… Am J Respir Crit Care Med 1999; 160: 132–136 … Am J Respir Crit Care Med 2001; 164:
396–340 … Am J Respir Crit Care Med 2001; 163: 1584–1590 …

Introduction Biomarkers can be useful for identifying or ruling out sepsis, identifying patients
who may benefit from specific therapies or assessing the response to therapy. Methods We …

Context Infection is a major cause of morbidity and mortality in intensive care units (ICUs)
worldwide. However, relatively little information is available about the global epidemiology of …

Objective: To provide an update to the original Surviving Sepsis Campaign clinical management
guidelines,“Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis …

Objective To provide an update to “Surviving Sepsis Campaign Guidelines for Management
of Sepsis and Septic Shock: 2012”. Design A consensus committee of 55 international …

Background Drotrecogin alfa (activated), or recombinant human activated protein C, has
antithrombotic, antiinflammatory, and profibrinolytic properties. In a previous study, drotrecogin …

… Vincent R. Moreno … A "Multiple Organ Dysfunction Score" was developed by J.
Marshall et al. [10] and a so-called "Brussels Score" [l 1] was developed by G. … Am J …

Importance Definitions of sepsis and septic shock were last revised in 2001. Considerable
advances have since been made into the pathobiology (changes in organ function, …

Objective: To provide an update to the “Surviving Sepsis Campaign Guidelines for
Management of Severe Sepsis and Septic Shock,” last published in 2008. Design: A consensus …