Human melanoma cells can process the MAGE-1 gene product and present the processed
nonapeptide EADPTGHSY on their major histocompatibility complex class I molecules, HLA-…

The discoveries of human melanoma-associated antigens in molecular terms have renewed
interest in peptide- or peptide- and antigen-presenting-cell (APC)-based cancer vaccines. …

Treatment with desmethylimipramine (DMI), a tricyclic antidepressant, for 7 to 21 days resulted
in a 35 to 45% decrease in the accumulation of adenosine cyclic 3':5'-monophosphate (…

Identification of human melanoma-associated peptide antigens for CTLs has opened
unprecedented opportunities for active specific immunotherapy for melanoma with synthetic peptide…

The intraventricular administration of 6-hydroxydopamine, a procedure which destroys
noradrenergic nerve terminals in the central nervous system, caused an increase in the density of …

The ontogeny of β-adrenergic receptors in rat cerebral cortex has been studied using [ 125 I]iodohydroxyzylpindolol
as a ligand in an in vitro binding assay. The concentration of β-…

Prostate-specific antigen (PSA) is a valuable marker antigen for prostate cancer. Lately
considerable interest has been generated in the prospect of developing a vaccine for prostate …

The intraventricular administration of 6-hydroxydopamine resulted in the destruction of
noradrenergic nerve terminals in the rat cerebral cortex and a 90% decrease in norepinephrine …

Because APCs play a crucial role in the generation of T cell-mediated immune responses,
numerous clinical trials with APC-based vaccines have been initiated in different types of …

… Requests for reprints should be addressed to Jonathan R. Sporn, MD, Division of
Hematology-Oncology, University of Connecticut Health Center, Farmington, Connecticut 06032. …