Airway mucus: the good, the bad, the sticky
CM Evans, JS Koo - Pharmacology & therapeutics, 2009 - Elsevier
Mucus production is a primary defense mechanism for maintaining lung health. However,
the overproduction of mucin (the chief glycoprotein component of mucus) is a common …
the overproduction of mucin (the chief glycoprotein component of mucus) is a common …
[HTML][HTML] Interleukin-1β and tumor necrosis factor-α induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases …
Mucin hypersecretion is commonly observed in many inflammatory diseases of the respiratory
tract. MUC5AC is generally recognized to be a major airway mucin because MUC5AC is …
tract. MUC5AC is generally recognized to be a major airway mucin because MUC5AC is …
CXCR2 expression in tumor cells is a poor prognostic factor and promotes invasion and metastasis in lung adenocarcinoma
…, SM Lippman, II Wistuba, WK Hong, JM Kurie, JS Koo - Cancer research, 2013 - AACR
CXCR2 in non–small cell lung cancer (NSCLC) has been studied mainly in stromal cells
and is known to increase tumor inflammation and angiogenesis. Here, we examined the …
and is known to increase tumor inflammation and angiogenesis. Here, we examined the …
[HTML][HTML] The BATTLE-2 study: a biomarker-integrated targeted therapy study in previously treated patients with advanced non–small-cell lung cancer
…, J Wang, AL Tam, KR Coombes, JS Koo… - Journal of clinical …, 2016 - ncbi.nlm.nih.gov
Purpose By applying the principles of real-time biopsy, biomarker-based, adaptively
randomized studies in non–small-cell lung cancer (NSCLC) established by the Biomarker-…
randomized studies in non–small-cell lung cancer (NSCLC) established by the Biomarker-…
Nonclassical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells
…, FH Tabassam, JH Yoon, JS Koo - Molecular biology of …, 2006 - Am Soc Cell Biol
Vitamin A (retinol) is essential for normal regulation of cell growth and differentiation. We have
shown that the retinol metabolite retinoic acid (RA) induces mucous cell differentiation of …
shown that the retinol metabolite retinoic acid (RA) induces mucous cell differentiation of …
Relative position of the hexahistidine tag effects binding properties of a tumor-associated single-chain Fv construct
A Goel, D Colcher, JS Koo, BJM Booth… - … et Biophysica Acta (BBA …, 2000 - Elsevier
Hexahistidine tag (His-tag) is the most widely used tag for affinity purification of recombinant
proteins for their structural and functional analysis. In the present study, single chain Fv (scFv…
proteins for their structural and functional analysis. In the present study, single chain Fv (scFv…
Interleukin-1β–induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A …
T Gray, P Nettesheim, C Loftin, JS Koo, J Bonner… - Molecular …, 2004 - ASPET
We reported recently that interleukin (IL)-1β exposure resulted in a prolonged increase in
MUC5AC mucin production in normal, well differentiated, human tracheobronchial epithelial (…
MUC5AC mucin production in normal, well differentiated, human tracheobronchial epithelial (…
Cyclic AMP response element-binding protein overexpression: a feature associated with negative prognosis in never smokers with non–small cell lung cancer
…, MK Kim, K Pisters, SM Lippman, II Wistuba, JS Koo - Cancer research, 2008 - AACR
Lung cancer is the leading cause of cancer deaths worldwide. Recent advances in targeted
therapies hold promise for the development of new treatments for certain subsets of cancer …
therapies hold promise for the development of new treatments for certain subsets of cancer …
[HTML][HTML] CHI3L1 regulates PD-L1 and anti–CHI3L1–PD-1 antibody elicits synergistic antitumor responses
…, CH He, JS Koo, CG Lee, JA Elias - The Journal of …, 2021 - Am Soc Clin Investig
Evasion of the immune response is a hallmark of cancer, and programmed cell death 1 (PD-1)
and PD-1 ligand 1 (PD-L1) are major mediators of this immunosuppression. Chitinase 3–…
and PD-1 ligand 1 (PD-L1) are major mediators of this immunosuppression. Chitinase 3–…
E2F8 as a novel therapeutic target for lung cancer
…, F López-Giráldez, RS Herbst, JS Koo - Journal of the …, 2015 - academic.oup.com
… Ja Seok Koo Ja Seok Koo … This work was supported by National Cancer Institute grant
R01-CA126801 (to Ja Seok Koo) and, in part, 5R01CA155196 (to Roy S. Herbst) and by National …
R01-CA126801 (to Ja Seok Koo) and, in part, 5R01CA155196 (to Roy S. Herbst) and by National …