User profiles for James Kean

James D. Kean

Orygen
Verified email at unimelb.edu.au
Cited by 590

Structure of class B GPCR corticotropin-releasing factor receptor 1

K Hollenstein, J Kean, A Bortolato, RKY Cheng… - Nature, 2013 - nature.com
Structural analysis of class B G-protein-coupled receptors (GPCRs), cell-surface proteins
that respond to peptide hormones, has been restricted to the amino-terminal extracellular …

The development of preschool children of heroin-addicted mothers: a controlled study

GS Wilson, R McCreary, J Kean, JC Baxter - Pediatrics, 1979 - publications.aap.org
Disturbances of growth and behavior in infants and toddlers of women addicted to heroin
during pregnancy have been reported in uncontrolled studies. In this study, 3to 6-year-old …

Intracellular allosteric antagonism of the CCR9 receptor

C Oswald, M Rappas, J Kean, AS Doré, JC Errey… - Nature, 2016 - nature.com
Chemokines and their G-protein-coupled receptors play a diverse role in immune defence by
controlling the migration, activation and survival of immune cells 1 . They are also involved …

Crystal structure of the GLP-1 receptor bound to a peptide agonist

A Jazayeri, M Rappas, AJH Brown, J Kean, JC Errey… - Nature, 2017 - nature.com
Glucagon-like peptide 1 (GLP-1) regulates glucose homeostasis through the control of insulin
release from the pancreas. GLP-1 peptide agonists are efficacious drugs for the treatment …

The Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review of Randomized, Controlled Human Clinical Trials

MP Pase, J Kean, J Sarris, C Neale… - The Journal of …, 2012 - liebertpub.com
Objectives: Traditional knowledge suggests that Bacopa monnieri enhances cognitive
performance. Such traditional beliefs have now been scientifically tested through a handful of …

Complementary medicines (herbal and nutritional products) in the treatment of Attention Deficit Hyperactivity Disorder (ADHD): a systematic review of the evidence

J Sarris, J Kean, I Schweitzer, J Lake - Complementary therapies in …, 2011 - Elsevier
OVERVIEW: Complementary and Alternative Medicines (CAMs) are frequently given to
children and adolescents for reputed benefits in the treatment of hyperkinetic and concentration …

An Acute, Double‐Blind, Placebo‐Controlled Crossover Study of 320 mg and 640 mg Doses of a Special Extract of Bacopa monnieri (CDRI 08) on Sustained …

LA Downey, J Kean, F Nemeh, A Lau… - Phytotherapy …, 2013 - Wiley Online Library
Standardized extracts of the traditional Ayurvedic medicine Bacopa monnieri (BM) (Brahmi)
have been recently shown to have cognitive enhancing effects in chronic administration …

[HTML][HTML] Digital technology for addressing cognitive impairment in recent-onset psychosis: a perspective

…, N Acevedo, A Stainton, K Nicol, J Kean… - Schizophrenia Research …, 2022 - Elsevier
Cognitive impairments in psychosis negatively impact functional recovery and quality of life.
Existing interventions for improving cognitive impairment in recent-onset psychosis show …

A systematic review of the Ayurvedic medicinal herb Bacopa monnieri in child and adolescent populations

JD Kean, LA Downey, C Stough - Complementary therapies in medicine, 2016 - Elsevier
Objectives Clinicians utilise critical research to advance their knowledge when prescribing
standard and alternative therapies for developmental disorders. Recent research has …

A molecular pharmacologist's guide to G protein–coupled receptor crystallography

CL Piscitelli, J Kean, C de Graaf, X Deupi - Molecular pharmacology, 2015 - ASPET
G protein–coupled receptor (GPCR) structural biology has progressed dramatically in the
last decade. There are now over 120 GPCR crystal structures deposited in the Protein Data …