The specific protein target of Δ 9 ‐tetrahydrocannabinol (Δ 9 ‐THC), the main active ingredient
of Cannabis sativa L., was characterized from rat brain nearly 20 years ago, and several …

Melatonin binding sites were localized and characterized in the vasculature of the rat by
using the melatonin analogue 2-[125I]iodomelatonin (125I-melatonin) and quantitative in vitro …

OBJECTIVE--The study was designed to examine the effects of age on sleep and the circadian
rhythms during consecutive night shifts. METHODS--Two groups of letter sorters (19-29 (…

Two endocannabinoids, arachidonoyl ethanolamide (AEA) and 2‐arachidonoylglycerol (2‐AG)
bind and activate G‐protein‐coupled cannabinoid receptors, but limited data exist on …

Increased expression of heme oxygenase-1 (HO-1) is a common feature in a number of
neurodegenerative diseases. Interestingly, the spatial distribution of HO-1 expression in …

In the central nervous system, three enzymes belonging to the serine hydrolase family are
thought to regulate the life time of the endocannabinoid 2-arachidonoylglycerol (C20:4) (2-AG)…

We have previously reported that the endocannabinoid, 2-arachidonoyl-glycerol (2-AG), is
hydrolyzed in rat cerebellar membranes by monoglyceride lipase (MGL)-like enzymatic activity…

2-Arachidonoylglycerol (2-AG) is an endogenous cannabinoid that binds to CB1 and CB2
cannabinoid receptors, inducing cannabimimetic effects. However, the cannabimimetic effects …

Melatonin is produced rhythmically by the pineal gland and the retina with increased
synthesis during darkness. Pineal melatonin serves as the ‘chemical expression of darkness’ …

Monoacylglycerol lipase (MAGL) terminates the signaling function of the endocannabinoid,
2-arachidonoylglycerol (2-AG). During 2-AG hydrolysis, MAGL liberates arachidonic acid, …