Background Antibiotics are life-saving drugs but severely affect the gut microbiome with
short-term consequences including diarrhea and selection of antibiotic-resistant bacteria. Long-…

The Drosophila (fruit fly) model system has been instrumental in our current understanding
of human biology, development, and diseases. Here, we used a high-throughput yeast two-…

Gem is a Ras-related protein whose expression is induced in several cell types upon activation
by extracellular stimuli. With the aim of isolating the cellular partners of Gem that mediate …

H-TWIST belongs to the family of basic helix–loop–helix (bHLH) transcription factors known
to exert their activity through dimer formation. We have demonstrated recently that mutations …

In this study, the performance of immobilised laccase (Trametes versicolor) was investigated
in combination with the mediator syringaldehyde (SYR) in removing a mixture of 38 …

Immune checkpoint inhibitors (ICIs) have dramatically improved patient outcomes in a variety
of tumor types, but with variable efficacy. Recent research has suggested that antibiotic-…

Post-translational modifications of GTPases from the Ras superfamily enable them to associate
with membrane compartments where they exert their biological activities. However, no …

Plasmalemmal caveolae are a membrane specialization that mediates transcytosis across
endothelial cells and the uptake of small molecules and ions by both epithelial and …

Lethal toxin (LT) from Clostridium sordellii is one of the high molecular mass clostridial
cytotoxins. On cultured cells, it causes a rounding of cell bodies and a disruption of actin stress …

This work describes the formation of transformation products (TPs) by the enzymatic
degradation at laboratory scale of two highly consumed antibiotics: tetracycline (Tc) and …