The decreasing number of approved drugs produced by the pharmaceutical industry, which
has been accompanied by increasing expenses for R&D, demands alternative approaches …

The purpose of this article is to delineate strategic considerations and provide practical
procedures to enable non-experts to synthesize peptides with a reasonable chance of success. …

In this paper, the computation of Sobol's sensitivity indices from the polynomial chaos
expansion of a model output involving uncertain inputs is investigated. It is shown that when the …

The creation of carbon-carbon bonds remains an important challenge in organic synthesis.
Numerous reactions for the formation of carbon-carbon bonds have been discovered and …

This paper presents the use of time series of SAR images to map the flood temporal dynamics
and the spatial distribution of vegetation over a large Amazonian floodplain. The region …

River systems connect the terrestrial biosphere, the atmosphere and the ocean in the global
carbon cycle 1 . A recent estimate suggests that up to 3 petagrams of carbon per year could …

To maintain homeostasis, hypothalamic neurons in the arcuate nucleus must dynamically
sense and integrate a multitude of peripheral signals. Blood-borne molecules must therefore …

This study addresses the quantification of the Amazon River sediment budget which has
been assessed by looking at data from a suspended sediment discharge monitoring network …

The floodplains of the Amazon basin influence the hydrology and fluxes of suspended solids
and solutes on multiple scales. Our study focused on the floodplain of Lago Grande de …

The objective of this study is to determine spatio-temporal variations of water volume over
inundated areas located in large river basins using combined observations from the Synthetic …