Structure-based design of potent non-peptide MDM2 inhibitors
…, Y Tomita, DA Parrish, JR Deschamps… - Journal of the …, 2005 - ACS Publications
A successful structure-based design of a class of non-peptide small-molecule MDM2
inhibitors targeting the p53−MDM2 protein−protein interaction is reported. The most potent …
inhibitors targeting the p53−MDM2 protein−protein interaction is reported. The most potent …
A hybrid quantum dot− antibody fragment fluorescence resonance energy transfer-based TNT sensor
We demonstrate the use of luminescent QDs conjugated to antibody fragments to develop
solution-phase nanoscale sensing assemblies, based on fluorescence resonance energy …
solution-phase nanoscale sensing assemblies, based on fluorescence resonance energy …
Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot–peptide conjugates
…, H Tetsuo Uyeda, EL Chang, JR Deschamps… - Nature materials, 2006 - nature.com
Proteases are enzymes that catalyse the breaking of specific peptide bonds in proteins and
polypeptides. They are heavily involved in many normal biological processes as well as in …
polypeptides. They are heavily involved in many normal biological processes as well as in …
Analyzing nanomaterial bioconjugates: a review of current and emerging purification and characterization techniques
…, KM Tyner, BJ Dair, JR Deschamps… - Analytical …, 2011 - ACS Publications
REVIEW be defined as the intersection of nanotechnology and biology and is loosely
characterized by two somewhat converse foci:(i) exploiting nanomaterials (NMs) to investigate …
characterized by two somewhat converse foci:(i) exploiting nanomaterials (NMs) to investigate …
1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors
PC Meltzer, D Butler, JR Deschamps… - Journal of medicinal …, 2006 - ACS Publications
Dopamine, serotonin, and norepinephrine are essential for neurotransmission in the mammalian
system. These three neurotransmitters have been the focus of considerable research …
system. These three neurotransmitters have been the focus of considerable research …
[PDF][PDF] Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance
…, JS Liow, RB Innis, K Cheng, KC Rice, JR Deschamps… - Cell metabolism, 2012 - cell.com
Obesity-related leptin resistance manifests in loss of leptin's ability to reduce appetite and
increase energy expenditure. Obesity is also associated with increased activity of the …
increase energy expenditure. Obesity is also associated with increased activity of the …
Sensing caspase 3 activity with quantum dot− fluorescent protein assemblies
We demonstrate the use of a hybrid fluorescent protein semiconductor quantum dot (QD)
sensor capable of specifically monitoring caspase 3 proteolytic activity. mCherry monomeric …
sensor capable of specifically monitoring caspase 3 proteolytic activity. mCherry monomeric …
Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors
…, V Ferey, JC Carry, JR Deschamps… - Journal of the …, 2013 - ACS Publications
Small-molecule inhibitors that block the MDM2-p53 protein–protein interaction (MDM2
inhibitors) are being intensely pursued as a new therapeutic strategy for cancer treatment. We …
inhibitors) are being intensely pursued as a new therapeutic strategy for cancer treatment. We …
Quantum dot DNA bioconjugates: attachment chemistry strongly influences the resulting composite architecture
K Boeneman, JR Deschamps, S Buckhout-White… - Acs Nano, 2010 - ACS Publications
The unique properties provided by hybrid semiconductor quantum dot (QD) bioconjugates
continue to stimulate interest for many applications ranging from biosensing to energy …
continue to stimulate interest for many applications ranging from biosensing to energy …
Ru2(ap)4(σ-oligo(phenyleneethynyl)) Molecular Wires: Synthesis and Electronic Characterization
…, JG Kushmerick, GL Xu, JR Deschamps… - Journal of the …, 2005 - ACS Publications
Reported in this contribution are the synthesis, characterization, and charge transport properties
of wire-like Ru 2 (ap) 4 (OPE n ), where ap is 2-anilinopyridinate and OPE is −(C⋮CC 6 …
of wire-like Ru 2 (ap) 4 (OPE n ), where ap is 2-anilinopyridinate and OPE is −(C⋮CC 6 …