Converging lines of evidence indicate that elevations in synaptic dopamine levels play a
pivotal role in the reinforcing effects of cocaine, which are associated with its abuse liability. …

A high-throughput screening campaign was conducted to interrogate a 380,000+ small-molecule
library for novel D2 dopamine receptor modulators using a calcium mobilization assay. …

The D1 dopamine receptor (D1R) has been implicated in numerous neuropsychiatric disorders,
and D1R-selective ligands have potential as therapeutic agents. Previous studies have …

Human hepatoma cells take up glutamine at rates severalfold faster than the system N-mediated
transport rates observed in normal human hepatocytes. Amino acid inhibition, kinetic, …

The purpose of this study was to characterize nicotine dependence and nicotine withdrawal
symptoms among adolescent smokers and to investigate associations between these key …

To assess the importance of brain cytochrome P450 (P450) activity in μ opioid analgesic
action, we generated a mutant mouse with brain neuron–specific reductions in P450 activity; …

The D 1 dopamine receptor is linked to a variety of neuropsychiatric disorders and represents
an attractive drug target for the enhancement of cognition in schizophrenia, Alzheimer …

Few studies have examined the long-term efficacy of computer-based smoking prevention
and cessation programs. We analyzed the long-term impact of A Smoking Prevention …

The D2 dopamine receptor (D2 DAR) is one of the most validated drug targets for
neuropsychiatric and endocrine disorders. However, clinically approved drugs targeting D2 DAR …

Rationale (−)-Stepholidine is a tetrahydroberberine alkaloid that is known to interact with
dopamine receptors and has also been proposed as a novel antipsychotic agent. Its suggested …