User profiles for Jeremie NEASTA

Jérémie Neasta

IBMM, Université de Montpellier, CNRS, ENSCM, Montpellier, France.
Verified email at umontpellier.fr
Cited by 1012

Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse

S Barak, F Liu, SB Hamida, QV Yowell, J Neasta… - Nature …, 2013 - nature.com
Relapse to alcohol abuse is an important clinical issue that is frequently caused by cue-induced
drug craving. Therefore, disruption of the memory for the cue-alcohol association is …

mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse

J Neasta, S Barak, SB Hamida… - Journal of …, 2014 - Wiley Online Library
The mammalian (or mechanistic) target of rapamycin ( mTOR ) complex 1 ( mTORC 1) is a
serine and threonine kinase that regulates cell growth, survival, and proliferation. mTORC 1 is …

Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders

J Neasta, S Ben Hamida, Q Yowell… - Proceedings of the …, 2010 - National Acad Sciences
Alcohol addiction is a chronically relapsing disorder that includes certain maladaptive learning
and memory. The serine and threonine kinase complex, mammalian target of rapamycin …

N-terminal liver-expressed antimicrobial peptide 2 (LEAP2) region exhibits inverse agonist activity toward the ghrelin receptor

…, S Dutertre, S Péraldi-Roux, J Neasta… - Journal of Medicinal …, 2018 - ACS Publications
The ghrelin receptor or growth hormone secretagogue receptor (GHSR) is a G-protein-coupled
receptor that controls growth hormone and insulin secretion, food intake, and reward-…

AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors

J Neasta, SB Hamida, QV Yowell, S Carnicella… - Biological …, 2011 - Elsevier
BACKGROUND: Neuroadaptations within the nucleus accumbens (NAc) have been implicated
in molecular mechanisms underlying the development and/or maintenance of alcohol …

[HTML][HTML] Epigenetic regulation of BDNF expression via the scaffolding protein RACK1

DY He, J Neasta, D Ron - Journal of Biological Chemistry, 2010 - ASBMB
Scaffolding proteins are major contributors to the spatial and temporal orchestration of
signaling cascades and hence cellular functions. RACK1 is a scaffolding protein that plays an …

The ellagitannin metabolite urolithin C is a glucose‐dependent regulator of insulin secretion through activation of L‐type calcium channels

M Bayle, J Neasta, M Dall'Asta… - British Journal of …, 2019 - Wiley Online Library
Background and Purpose The pharmacology of polyphenol metabolites on beta‐cell function
is largely undetermined. We sought to identify polyphenol metabolites that enhance the …

[HTML][HTML] Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription

J Neasta, PA Kiely, DY He, DR Adams… - Journal of Biological …, 2012 - ASBMB
RACK1 is a scaffolding protein that spatially and temporally regulates numerous signaling
cascades. We previously found that activation of the cAMP signaling pathway induces the …

The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors

SB Hamida, J Neasta, AW Lasek… - Journal of …, 2012 - Soc Neuroscience
Uncontrolled consumption of alcohol is a hallmark of alcohol abuse disorders; however, the
central molecular mechanisms underlying excessive alcohol consumption are still unclear. …

Protection of pancreatic β-cell function by dietary polyphenols

M Dall'Asta, M Bayle, J Neasta, F Scazzina… - Phytochemistry …, 2015 - Springer
Diabetes mellitus is a complex metabolic disorder and is considered a fast-growing global
health problem. Type 2 diabetes (T2D) represents the majority of total diabetes prevalence …