User profiles for Jerzy W. Mozrzymas

Jerzy Mozrzymas

Professor of Biological Sciences, Wroclaw Medical University
Verified email at umed.wroc.pl
Cited by 3462

Influence of matrix metalloproteinase MMP-9 on dendritic spine morphology

…, D Muller, GM Wilczynski, JW Mozrzymas… - Journal of cell …, 2011 - journals.biologists.com
An increasing body of data has shown that matrix metalloproteinase-9 (MMP-9), an extracellularly
acting, Zn 2+ -dependent endopeptidase, is important not only for pathologies of the …

Modulation of GABAA receptors by hydrogen ions reveals synaptic GABA transient and a crucial role of the desensitization process

JW Mozrzymas, ED Żarmowska, M Pytel… - Journal of …, 2003 - Soc Neuroscience
Protons are the most ubiquitous and very potent modulators of the biological systems.
Hydrogen ions are known to modulate GABA A receptors (GABA A Rs), but the mechanism …

CD44: a novel synaptic cell adhesion molecule regulating structural and functional plasticity of dendritic spines

…, E Rejmak, E Knapska, JW Mozrzymas… - Molecular Biology of …, 2016 - Am Soc Cell Biol
Synaptic cell adhesion molecules regulate signal transduction, synaptic function, and plasticity.
However, their role in neuronal interactions with the extracellular matrix (ECM) is not well …

LEF1/β-catenin complex regulates transcription of the Cav3. 1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain

…, A Nagalski, JW Mozrzymas… - Journal of …, 2010 - Soc Neuroscience
β-Catenin, together with LEF1/TCF transcription factors, activates genes involved in the
proliferation and differentiation of neuronal precursor cells. In mature neurons, β-catenin …

Binding sites, singly bound states, and conformation coupling shape GABA-evoked currents

JW Mozrzymas, A Barberis, K Mercik… - Journal of …, 2003 - journals.physiology.org
The time course of GABA-evoked currents is the main source of information on the GABA A
receptor gating. Since the kinetics of these currents depends on the transitions between …

Maintenance of long‐term potentiation in hippocampal mossy fiber—CA3 pathway requires fine‐tuned MMP‐9 proteolytic activity

…, M Bajor, L Kaczmarek, JW Mozrzymas - …, 2013 - Wiley Online Library
Mechanisms of synaptic plasticity involve proteolytic activity mediated by a complex system
of proteases, including members of metalloproteinase (MMP) family. In particular, MMP‐9 is …

[HTML][HTML] Extracellular metalloproteinases in the plasticity of excitatory and inhibitory synapses

G Wiera, JW Mozrzymas - Cells, 2021 - mdpi.com
Long-term synaptic plasticity is shaped by the controlled reorganization of the synaptic
proteome. A key component of this process is local proteolysis performed by the family of …

Mechanisms of NMDA receptor-and voltage-gated L-type calcium channel-dependent hippocampal LTP critically rely on proteolysis that is mediated by distinct …

…, P Dziegiel, L Moons, JW Mozrzymas - Journal of …, 2017 - Soc Neuroscience
Long-term potentiation (LTP) is widely perceived as a memory substrate and in the hippocampal
CA3-CA1 pathway, distinct forms of LTP depend on NMDA receptors (nmdaLTP) or L-…

Chlorpromazine inhibits miniature GABAergic currents by reducing the binding and by increasing the unbinding rate of GABAAReceptors

JW Mozrzymas, A Barberis, K Michalak… - Journal of …, 1999 - Soc Neuroscience
Recent studies have emphasized that nonequilibrium conditions of postsynaptic GABA A
receptor (GABA A R) activation is a key factor in shaping the time course of IPSCs ( Puia et al., …

Desensitization and binding properties determine distinct α1β2γ2 and α3β2γ2 GABAA receptor‐channel kinetic behavior

A Barberis, JW Mozrzymas, PI Ortinski… - European Journal of …, 2007 - Wiley Online Library
GABA A receptor subtypes comprising the α1 and α3 subunits change with development
and have a specific anatomical localization in the adult brain. These receptor subtypes have …