Two rat calcitonin receptor isoforms have been identified by cDNA cloning from a hypothalamic
library. The clones, C1a and C1b, specified proteins of 478 and 515 amino acids, …

The structure/function relationship of salmon calcitonin (sCT) analogues was investigated in
heterologous calcitonin receptor (CTR) expression systems. sCT analogues with …

Although high densities of calcitonin (CT) receptors and protein CT-induced actions occur
within the central nervous system, the physiological ligand for central receptors remains …

Despite the fact that inositol hexakisphosphate (InsP 6 ) is the most abundant inositol metabolite
in cells, its cellular function has remained an enigma. In the present study, we present …

Accumulating evidence supports the existence of nonthyroidal calcitonin (CT)-like peptides,
more similar to fish CTs, which may act as endogenous regulators of CT receptors in brain …

Mixed lineage kinase domain-like (MLKL) is a component of the "necrosome," the multiprotein
complex that triggers tumor necrosis factor (TNF)-induced cell death by necroptosis. To …

Recognizing the imperative to evaluate species recovery and conservation impact, in 2012
the International Union for Conservation of Nature (IUCN) called for development of a “Green …

MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have
isolated a mouse strain with a single missense mutation, Mlkl D139V , that alters the two-…

Americans have long recognized that investments in public education contribute to the common
good, enhancing national prosperity and supporting stable families, neighborhoods, and …