[HTML][HTML] Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity
…, TP Combs, MW Rajala, T Doebber, JP Berger… - Journal of Biological …, 2004 - ASBMB
Adiponectin is an adipocyte-specific secretory protein that circulates in serum as a hexamer
of relatively low molecular weight (LMW) and a larger multimeric structure of high molecular …
of relatively low molecular weight (LMW) and a larger multimeric structure of high molecular …
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors
L Michalik, J Auwerx, JP Berger, VK Chatterjee… - Pharmacological …, 2006 - ASPET
The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated
transcription factors of the nuclear hormone receptor superfamily. They share a high degree of …
transcription factors of the nuclear hormone receptor superfamily. They share a high degree of …
[HTML][HTML] Integrated genomic and proteomic analyses of gene expression in mammalian cells
Using DNA microarrays together with quantitative proteomic techniques (ICAT reagents, two-dimensional
DIGE, and MS), we evaluated the correlation of mRNA and protein levels in …
DIGE, and MS), we evaluated the correlation of mRNA and protein levels in …
PPARs: therapeutic targets for metabolic disease
JP Berger, TE Akiyama, PT Meinke - Trends in pharmacological sciences, 2005 - cell.com
The three peroxisome-proliferator-activated receptor (PPAR) subtypes, PPAR-γ, PPAR-α and
PPAR-δ, are nuclear receptors that have been the focus of extensive research during the …
PPAR-δ, are nuclear receptors that have been the focus of extensive research during the …
Retinaldehyde represses adipogenesis and diet-induced obesity
…, G Orasanu, M Sharlach, TE Akiyama, JP Berger… - Nature medicine, 2007 - nature.com
The metabolism of vitamin A and the diverse effects of its metabolites are tightly controlled
by distinct retinoid-generating enzymes, retinoid-binding proteins and retinoid-activated …
by distinct retinoid-generating enzymes, retinoid-binding proteins and retinoid-activated …
Distinct properties and advantages of a novel peroxisome proliferator-activated protein γ selective modulator
JP Berger, AE Petro, KL Macnaul, LJ Kelly… - Molecular …, 2003 - academic.oup.com
Antidiabetic thiazolidinediones (TZDs) and non-TZD compounds have been shown to serve
as agonists of the peroxisome proliferator-activated receptor γ (PPARγ). Here, we report the …
as agonists of the peroxisome proliferator-activated receptor γ (PPARγ). Here, we report the …
[HTML][HTML] Hyperglycemia-induced production of acute phase reactants in adipose tissue
Y Lin, MW Rajala, JP Berger, DE Moller… - Journal of Biological …, 2001 - ASBMB
Chronic elevation of systemic levels of acute phase reactants and inflammatory cytokines
found in patients with diabetes and the often-associated metabolic syndrome X (…
found in patients with diabetes and the often-associated metabolic syndrome X (…
Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor γ and altered metabolic states
Adipose tissue is a metabolically responsive endocrine organ that secretes a myriad of
adipokines. Antidiabetic drugs such as peroxisome proliferator-activated receptor (PPAR) γ …
adipokines. Antidiabetic drugs such as peroxisome proliferator-activated receptor (PPAR) γ …
An integrative genomics approach to the reconstruction of gene networks in segregating populations
…, SW Edwards, R Thieringer, JP Berger… - … and genome research, 2004 - karger.com
The reconstruction of genetic networks in mammalian systems is one of the primary goals in
biological research, especially as such reconstructions relate to elucidating not only common…
biological research, especially as such reconstructions relate to elucidating not only common…
FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents
…, DM Zaller, BB Zhang, RD DiMarchi, JP Berger… - Diabetes, 2012 - Am Diabetes Assoc
Fibroblast growth factor 21 (FGF21) mitigates many of the pathogenic features of type 2
diabetes, despite a short circulating half-life. PEGylation is a proven approach to prolonging the …
diabetes, despite a short circulating half-life. PEGylation is a proven approach to prolonging the …