The insulin/insulin growth factor (IGF) signaling (IIS) pathway is a key regulator of aging of
worms, flies, mice, and likely humans. Delayed aging by IIS reduction protects the nematode C…

Several proteins have been identified as amyloid forming in humans, and independent of
protein origin, the fibrils are morphologically similar. Therefore, there is a potential for …

The amyloid present in the islets of Langerhans in type 2 diabetes is polymerized islet
amyloid polypeptide (IAPP). The precursor protein proIAPP is posttranslationally modified, a …

Alpha-synuclein (α-syn) aggregation is a neuropathological hallmark of many diseases
including Dementia with Lewy Bodies (DLB) and Parkinson's Disease (PD), collectively termed …

Accumulation of amyloid β-peptide (Aβ) and tau aggregates, possibly linked to age-associated
deficiencies in protein homeostasis, appear to cause Alzheimer's disease. Schiff-base …

Peptides are notoriously known to display very short in vivo half-lives often measured in
minutes which in many cases greatly reduces or eliminates sufficient in vivo efficacy. To obtain …

The two gut hormones GLP‐1 and PYY 3–36 , which are both secreted from the L‐cells
upon food stimuli, have a stronger inhibitory effect on food intake when they are combined, …

Cell-autonomous and cell-nonautonomous mechanisms of neurodegeneration appear to
occur in the proteinopathies, including Alzheimer’s and Parkinson’s diseases. However, how …

Aims/Hypothesis Islet amyloid polypeptide (IAPP) is a beta cell hormone secreted together
with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but …

Following the encouraging report of the Edmonton group, there was a rejuvenation of the
islet transplantation field. After that, more pessimistic views spread when long-term results of …