[HTML][HTML] Reduced IGF-1 signaling delays age-associated proteotoxicity in mice
The insulin/insulin growth factor (IGF) signaling (IIS) pathway is a key regulator of aging of
worms, flies, mice, and likely humans. Delayed aging by IIS reduction protects the nematode C…
worms, flies, mice, and likely humans. Delayed aging by IIS reduction protects the nematode C…
[HTML][HTML] In vivo seeding and cross-seeding of localized amyloidosis: a molecular link between type 2 diabetes and Alzheimer disease
ME Oskarsson, JF Paulsson, SW Schultz… - The American journal of …, 2015 - Elsevier
Several proteins have been identified as amyloid forming in humans, and independent of
protein origin, the fibrils are morphologically similar. Therefore, there is a potential for …
protein origin, the fibrils are morphologically similar. Therefore, there is a potential for …
Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation
JF Paulsson, GT Westermark - Diabetes, 2005 - Am Diabetes Assoc
The amyloid present in the islets of Langerhans in type 2 diabetes is polymerized islet
amyloid polypeptide (IAPP). The precursor protein proIAPP is posttranslationally modified, a …
amyloid polypeptide (IAPP). The precursor protein proIAPP is posttranslationally modified, a …
Lovastatin ameliorates α-synuclein accumulation and oxidation in transgenic mouse models of α-synucleinopathies
AO Koob, K Ubhi, JF Paulsson, J Kelly… - Experimental …, 2010 - Elsevier
Alpha-synuclein (α-syn) aggregation is a neuropathological hallmark of many diseases
including Dementia with Lewy Bodies (DLB) and Parkinson's Disease (PD), collectively termed …
including Dementia with Lewy Bodies (DLB) and Parkinson's Disease (PD), collectively termed …
Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity
K Usui, JD Hulleman, JF Paulsson… - Proceedings of the …, 2009 - National Acad Sciences
Accumulation of amyloid β-peptide (Aβ) and tau aggregates, possibly linked to age-associated
deficiencies in protein homeostasis, appear to cause Alzheimer's disease. Schiff-base …
deficiencies in protein homeostasis, appear to cause Alzheimer's disease. Schiff-base …
[HTML][HTML] The effect of fatty diacid acylation of human PYY3-36 on Y2 receptor potency and half-life in minipigs
S Østergaard, JF Paulsson, J Kofoed, F Zosel… - Scientific Reports, 2021 - nature.com
Peptides are notoriously known to display very short in vivo half-lives often measured in
minutes which in many cases greatly reduces or eliminates sufficient in vivo efficacy. To obtain …
minutes which in many cases greatly reduces or eliminates sufficient in vivo efficacy. To obtain …
The design of a GLP‐1/PYY dual acting agonist
S Østergaard, JF Paulsson… - Angewandte Chemie …, 2021 - Wiley Online Library
The two gut hormones GLP‐1 and PYY 3–36 , which are both secreted from the L‐cells
upon food stimuli, have a stronger inhibitory effect on food intake when they are combined, …
upon food stimuli, have a stronger inhibitory effect on food intake when they are combined, …
Cellular clearance of circulating transthyretin decreases cell-nonautonomous proteotoxicity in Caenorhabditis elegans
…, N Rouzbeh, CA Aguirre, JF Paulsson… - Proceedings of the …, 2018 - National Acad Sciences
Cell-autonomous and cell-nonautonomous mechanisms of neurodegeneration appear to
occur in the proteinopathies, including Alzheimer’s and Parkinson’s diseases. However, how …
occur in the proteinopathies, including Alzheimer’s and Parkinson’s diseases. However, how …
[HTML][HTML] High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus
JF Paulsson, J Ludvigsson, A Carlsson, R Casas… - PloS one, 2014 - journals.plos.org
Aims/Hypothesis Islet amyloid polypeptide (IAPP) is a beta cell hormone secreted together
with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but …
with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but …
[HTML][HTML] Amyloid deposition in transplanted human pancreatic islets: a conceivable cause of their long-term failure
…, S Bohman, LA Borg, JF Paulsson… - Journal of Diabetes …, 2008 - hindawi.com
Following the encouraging report of the Edmonton group, there was a rejuvenation of the
islet transplantation field. After that, more pessimistic views spread when long-term results of …
islet transplantation field. After that, more pessimistic views spread when long-term results of …