Mutations in the HERG K + channel gene cause inherited long QT syndrome (LQT), a
disorder of cardiac repolarization that predisposes affected individuals to lethal arrhythmias [Curran…

Isolated adult cardiac myocytes maintained in primary culture have been used as a model
of the adult myocardium for 20 years. With the recent advances and current interest in using …

Avoiding drug-induced cardiac arrhythmia is recognized as a major hurdle in the successful
development of new drugs. The most common problem is acquired long QT syndrome …

Deactivation of voltage-gated potassium (K + ) channels can slow or prevent the recovery
from block by charged organic compounds, a phenomenon attributed to trapping of the …

Drug-induced block of cardiac hERG K + channels causes acquired long QT syndrome.
Here, we characterized the molecular mechanism of hERG block by two low-potency drugs (…

The configuration of cardiac action potentials varies considerably from one region of the
heart to another. These differences are caused by differential cellular expression of several …

Voltage-gated channels are normally opened by depolarization and closed by repolarization
of the membrane. Despite sharing significant sequence homology with voltage-gated K + …

Adult rabbit ventricular myocytes were cultured in a basic medium (Medium 199) for up to 6
days to assess preservation of morphology and ion channel currents. In culture, cells …

Many commonly used, structurally diverse, drugs block the human ether‐a‐go‐go‐related
gene (hERG) K + channel to cause acquired long QT syndrome, which can lead to sudden …

hERG potassium channels have a critical role in the normal electrical activity of the heart. The
block of hERG channels can cause the drug-induced form of long QT syndrome, a cardiac …