User profiles for John W Hanrahan

John W. Hanrahan

McGill University
Verified email at mcgill.ca
Cited by 15333

Cutting edge: 1, 25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression

…, L Tavera-Mendoza, R Lin, JW Hanrahan… - The Journal of …, 2004 - journals.aai.org
The hormonal form of vitamin D 3, 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), is an immune
system modulator and induces expression of the TLR coreceptor CD14. 1, 25 (OH) 2 D 3 …

Phosphorylation-regulated CI channel in CHO cells stably expressing the cystic fibrosis gene

JA Tabcharani, XB Chang, JR Riordan, JW Hanrahan - Nature, 1991 - nature.com
A CYCLIC AMP-stimulated choride conductance appears when the cystic fibres is gene is
expressed in non-epithelial cells by infection with recombinant viruses 1,2 . Cyclic AMP-…

Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance

N Kartner, JW Hanrahan, TJ Jensen, AL Naismith… - Cell, 1991 - cell.com
The nature of involvement of the cystic fibrosis gene product (CFTR) in epithelial anion
transport is not yet understood. We have expressed CFTR in Sf9 insect cells using the …

Glutathione permeability of CFTR

P Linsdell, JW Hanrahan - American Journal of Physiology …, 1998 - journals.physiology.org
The cystic fibrosis transmembrane conductance regulator (CFTR) forms an ion channel that
is permeable both to Cl − and to larger organic anions. Here we show, using macroscopic …

Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers

AM Cantin, JW Hanrahan, G Bilodeau… - American journal of …, 2006 - atsjournals.org
Rationale: Cigarette smoke extract inhibits chloride secretion in human bronchial epithelial
cells. Oxidants decrease gene expression, protein expression, and function of the cystic …

Physiology of epithelial chloride and fluid secretion

RA Frizzell, JW Hanrahan - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Epithelial salt and water secretion serves a variety of functions in different organ systems,
such as the airways, intestines, pancreas, and salivary glands. In cystic fibrosis (CF), the …

Permeability of wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels to polyatomic anions

…, LC Tsui, JR Riordan, JW Hanrahan - The Journal of general …, 1997 - rupress.org
Permeability of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride
channel to polyatomic anions of known dimensions was studied in stably transfected Chinese …

[HTML][HTML] Phosphorylation by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A

Y Jia, CJ Mathews, JW Hanrahan - Journal of Biological Chemistry, 1997 - ASBMB
Protein kinase A (PKA) stimulates Cl secretion by activating the cystic fibrosis transmembrane
conductance regulator (CFTR), a tightly regulated Cl − channel in the apical membrane of …

CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli

R Grygorczyk, JW Hanrahan - American Journal of …, 1997 - journals.physiology.org
Cystic fibrosis transmembrane conductance regulator (CFTR)-mediated ATP efflux has been
proposed as an autocrine mechanism for regulating chloride secretion through other types …

[HTML][HTML] BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRΔF508 via the derlin-1 complex

…, D Zhang, N Nguyen, DY Thomas, JW Hanrahan… - Cell, 2008 - cell.com
BAP31 is an endoplasmic reticulum protein-sorting factor that associates with newly
synthesized integral membrane proteins and controls their fate (ie, egress, retention, survival, or …