The role of cAMP/cAMP-dependent protein kinase (PKA) on the late phase of exocytosis
has been studied by amperometry on Ba 2+ -stimulated single bovine chromaffin cells. …

Several drugs produce rapid changes in the kinetics of exocytosis of catecholamines, as
measured at the single event level with amperometry. This study is intended to unveil whether …

Secretory vesicles of sympathetic neurons and chromaffin granules maintain a pH gradient
toward the cytosol (pH 5.5 versus 7.2) promoted by the V-ATPase activity. This gradient of pH …

Chromogranins/secretogranins (Cgs) are the major soluble proteins of large dense-core
secretory vesicles (LDCVs). We have recently reported that the absence of chromogranin A (…

… (d) Analysis of the cumulative secretion over a 2-min recording (means ± SEM). (e) The net
… (d) Cumulative secretion obtained as described in the legend of Fig. 1. (e) The net spike …

The effects of nitric oxide (NO) on the late phase of exocytosis have been studied, by
amperometry, on Ba 2+ -stimulated chromaffin cells. Acute incubation with NO or NO donors (…

Chromogranins (Cgs) are acidic proteins that have been implicated in several physiological
processes such as vesicle sorting, the production of bioactive peptides and the …

The effects of the antihypertensive agent hydralazine (1 to 100 nmol/L) on the exocytotic
process of single adrenal chromaffin cells have been studied using amperometry. Hydralazine …

Secretory vesicles of sympathetic neurons and chromaffin granules maintain a pH gradient
towards the cytosol (5.5 vs. 7.2) promoted by the V-ATPase activity. This gradient of pH is …

The accumulation of neurotransmitters within secretory vesicles ( SV s) far exceeds the
theoretical tonic concentrations in the cytosol, a phenomenon that has captivated the attention of …