User profiles for José R. Lopez

Jose R Lopez

- Verified email at MSMC.com - Cited by 9714

José Ramón López López

- Verified email at uva.es - Cited by 5072

Local calcium transients triggered by single L-type calcium channel currents in cardiac cells

JR López-López, PS Shacklock, CW Balke, WG Wier - Science, 1995 - science.org
Excitation-contraction coupling was studied in mammalian cardiac cells in which the opening
probability of L-type calcium (Ca 2+ ) channels was reduced. Confocal microscopy during …

Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice

JR Lopez, A Lyckman, S Oddo… - Journal of …, 2008 - Wiley Online Library
Neurodegeneration in Alzheimer’s disease (AD) has been linked to intracellular accumulation
of misfolded proteins and dysregulation of intracellular Ca 2+ . In the current work, we …

[HTML][HTML] TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

…, P Reeh, MT Pérez-García, JR López-López… - Nature …, 2014 - nature.com
Gram-negative bacterial infections are accompanied by inflammation and somatic or
visceral pain. These symptoms are generally attributed to sensitization of nociceptors by …

Chemotransduction in the Carotid Body: K+ Current Modulated by PO2 In Type I Chemoreceptor Cells

J López-Barneo, JR López-López, J Ureña… - Science, 1988 - science.org
The ionic currents of carotid body type I cells and their possible involvement in the detection
of oxygen tension (PO 2 ) in arterial blood are unknown. The electrical properties of these …

Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective study

…, J Dasarathy, A Khiyami, R Joseph, R Lopez… - Journal of …, 2009 - Elsevier
BACKGROUND/AIMS: Ultrasound is used to screen for hepatic steatosis, the most common
liver disease in the United States. However, few studies have prospectively evaluated the …

O2 Modulates Large-Conductance Ca2+-Dependent K+ Channels of Rat Chemoreceptor Cells by a Membrane-Restricted and CO-Sensitive Mechanism

AM Riesco-Fagundo, MT Pérez-García… - Circulation …, 2001 - Am Heart Assoc
Hypoxic inhibition of large-conductance Ca 2+ -dependent K + channels (maxiK) of rat carotid
body type I cells is a well-established fact. However, the molecular mechanisms of such …

Kvβ1.2 Subunit Coexpression in HEK293 Cells Confers O2 Sensitivity to Kv4.2 but not to Shaker Channels

MT Pérez-García, JR López-López… - The Journal of general …, 1999 - rupress.org
Voltage-gated K + (K V ) channels are protein complexes composed of ion-conducting integral
membrane α subunits and cytoplasmic modulatory β subunits. The differential expression …

[HTML][HTML] Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia

…, X Ding, IN Pessah, PD Allen, JR Lopez - The FASEB …, 2013 - ncbi.nlm.nih.gov
Malignant hyperthermia (MH) susceptibility has been attributed to a leaky sarcoplasmic
reticulum (SR) caused by missense mutations in RYR1 or CACNA1S, and the MH crisis has …

Kv1. 3 channels can modulate cell proliferation during phenotypic switch by an ion-flux independent mechanism

…, C Ruiz-McDavitt, JR López-López… - … , and vascular biology, 2012 - Am Heart Assoc
Objective— Phenotypic modulation of vascular smooth muscle cells has been associated
with a decreased expression of all voltage-dependent potassium channel (Kv)1 channel …

[HTML][HTML] Altered ROS production, NF-κB activation and interleukin-6 gene expression induced by electrical stimulation in dystrophic mdx skeletal muscle cells

…, F Altamirano, D Valladares, JR López… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Duchenne muscular dystrophy is a fatal X-linked genetic disease, caused by mutations in
the dystrophin gene, which cause functional loss of this protein. This pathology is associated …